Uddannelses- og Forskningsudvalget 2023-24
UFU Alm.del Bilag 41
Offentligt
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The four
manthra’s
on education and research politics
Uddannelses- og Forskningsudvalget 2023-24
UFU Alm.del - Bilag 41
Offentligt
Four
Manthra’s
•
Chemistry is Everything
•
Youth for Chemistry
•
Research with no Restraints
•
Funding by Performance
Morten Meldal @ Department of Chemistry @ University of Copenhagen, Denmark
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Where does it all come from?
The road to success is never straight
Science projects almost always fails initially
You
cannot
plan so look for opportunity
Many factors determining your path
Fails and rise again
Time is precious use it optimally
Do what
YOU
find interesting/important
Get out of your comfort zone
Change field occasionally
Bring your experience to use
Study all your life
Intuition
Imagination
Association
Observation
Combination
Creativity
Collaboration
Courage
Perseverance
Computation
Factual knowledge
Idea……experiment……observation…… understanding…….repetition
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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SPOCC: Merging peptide diversity with organic chemistry
DTU
Cambridge LMB
University of Copenhagen
Carlsberg Laboratory
University of Copenhagen
Solid phase organic
combinatorial chemistry center
SPOCC
On resin QCTs:
O
Diels-Alder
O
N
O
H
n
Aldol
R
Nitroaldol
R
O
H
2
N
O
Glycosylation
n
R
Transaminations
O
O
N
O
Metathesis
H
n
Wittig-reactions
Redox-reactions
Dihydroxylation-oxidations
WHE-reactions
C-Allylations
Phosphorylations
Sulfatations
Silylations
CuAAC-reactions
N-Acyl
iminium ion reactions
N-Carbamyl
iminium reactions
Carbene chemistry
Phosphine chemistry
Palladation
Catalytic C-C bond formations
Sonogashira
Suzuki
H
N
O
H
N
O
H
N
O
R
R
On resin QCTs:
Glycopeptides
Proteases
Glycosylases
Glycosyl transferases
Isomerases
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Chemistry is the bread and butter of the Danish knowledge based society
Chemistry is essential
Medicine
Materials
Food sector
Energy
Production
Agriculture
Devices
Electronics
Defense
Going green
Regional top15 chemistry companies
Novo Nordisk / NNF
Novozymes
Leo Pharmaceuticals
Lundbeck + fond
Topsoe
Zealand
Alka Bello
Portland
F.L. Smidth
Carlsberg + Fond
Christian Hansen
ChemiNova
Dupont DK
Coloplast
Danfoss
Chemistry is a wet science and learning chemistry is a balance of theory and experiments
Education for a MSc in chemistry is only possible with a 3 year BSc and a 2 year MSc
Denmark has one of the shortest most constrained PhD formats in the world
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Shaping of talents….. for the chemistry based society
Factors of influence for choice of education
Education relate to identity
1.
2.
3.
4.
5.
6.
7.
Knowledge
Parental influence
Institutional influence
Courage and identity
Status and opportunity
Salary
Existential curiosity
Identity building starts early
Identity building is largely emotional
Identity from parental identity
Identity from friends
Identity by believe in authority
Identity by knowledge
Identity via influence / media
Educations matching societal needs
How to optimize the creation of identity and selection of education
Efficient education is without external pressure
Knowledge and authority
Positive reinforcement and self-esteem
START EARLY
REWARD SELECTION
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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The DG Centers attract many talents…….Example SPOCC
Idea:
Develop organic reactions for solid phase combinatorial chemistry at the level of peptide chemistry
Combining QCT reactions with peptide diversity
New chemistry and novel structures towards drug development and material science
Process:
Change of subject at Department of Chemistry, Carlsberg Laboratory
Application by MPM and KB
Composing an application with a strong component of new fundamental research
Tight fit between the core of the application and the hiring plan
Strong component of education in the program
Strong international composition and collaboration
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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The DG Centers attract many talents…….Example SPOCC
The group: Critical mass and infrastructure
Infrastructure…. Infrastructure….. Infrastructure
Multidisciplinary from physical chemistry to biology
Diverse composed of researchers from around the world
Group size: up to 25 total and ~15 on average for ten years
Reporting and dialogue with DG:
Short annual report and meeting with DG
…….results,
publications and future plans
Excellent dialog with DG at the SPOCC center
Very positive forward looking, no administration
Request for 30% novel plans annually
Short resume of negotiated actions for the coming year
Working at the SPOCC center:
Surprisingly excellent applicants and talents considering the private nature of CL
MPM and KB networks were of great importance in personnel atraction
Very short efficient process of decision and action (Shorter than on the universities)
The continuation of DG is of great importance for the future of Denmark as a knowledge based society
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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The SPOCC-CECB Platform Technology
Indicator,
property modifier
auxhiliary molecule
Identity tag
Reactive library
component
Central to all biological
phenomena is specific
molecular recognition
Library
5h
H- k
l
h r
i
r
a
-OH
Hit
Inactive
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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CECB at University of Copenhagen
Center of Evolutionary Chemical Biology…..CECB….. a lighthouse center at KU:
Chemical biology from a chemical perspective
Using combinatorial organic chemistry, protein expression and cellular studies,
Medicinal chemistry projects fitting requirements of Danish industry
Direct result
of the SPOCC center (as in ”not
possible without”)
Platform technology developed at Carlsberg Laboratory was used
Up to 22 coworkers, very diverse group
Lot of expertise in complementary fields within the group
Very positive midterm evaluation
Application to NNF and Villum to continue was rejected
2022
……
Nobel Prize in Chemistry
THANK YOU to the Danish National Research Foundation & UCPH
Comparing developing countries with Denmark: Saudi Arabia, Vietnam and India
Research centers with infrastructure areof great importance for the future of Denmark as a knowledge based society
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Two chemistry toolboxes
The large organic toolbox
Uncatalyzed
Catalyzed x 10
7
The small orthogonal Click toolbox
CW Tornøe & M Meldal
Intramolecular
reactions
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Youth for Chemistry:
…….
Chemistry is much more than an education
Chemistry is Everything
A global education initiative
Chemistry curriculum early
Pleasure driven learning
Images rather than text
Start early, start positive
Excite excite excite
Visualization before quantification
Evolve STEM interest
Young store images, even abstract
~ Five years without formulas
No examinations until six grade
Visualization, Videos, VR, exp
The positive consequences of early global
introduction to chemistry could be monumental
Environmentally
Climatically
Politically
Religiously
For global equality
For our resources
For wealth distributions
For peace transitions
For health and professions
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Digital Animated Chemistry Archive (Danche)
Video, VR, Text sent to teachers and kids
60 min/week Grade 9
60 min/week Grade 8
50 min/week Grade 7
40 min/week Grade 6
30 min/week Grade 5
20 min/week Grade 4
15 min/week Grade 3
10 min/week Grade 2
Danche
How can I help
Filtered
Indexed
and Licensed
Material form the
internet
5 min/week Grade 1
Translation and globalization unit
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Chemistry:
…….
Much more than an education
Tools for schools
Young in chemistry
Transformative understanding
In three dimensions
MOLEGO : Molecular LEGO building system
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Facilitation of research through funding without restraints
Most of the great and disruptive discoveries are
SERENDIPITOUS (otherwise its unlikely to be new)
Just look at Nobel Prize discoveries
What we want in Research funding is:
Productivity
Quality
Creativity & Novelty
Responsibility
Translation
Today
All research
Fundamental
Applied
Great ideas are usually an afterthought to on odd
behavior (e.g. Penicillin, Click chemistry, Suzuki
reactions, Structure of atoms, Transistors etc)
Two completely independent
funding regimes
Disruptive novel research to
secure the future in competition
Optimization & application
of known research results
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Chemistry Challenges : One driver could be the green agenda
New sustainable materials
Construction materials
Replacement of fossils
Packeting with cellulose
Textile materials
Green polymer
Increased and improved food
Produced at location
Adaptation to climate
The fertilizer issues
Packeting issues in consumption
Processing tools
New production processes
Less environment impact
Less waste and energy
Less depletion of resources
Production at location
Textiles and clothing
Production at location
Recycling of fibers
Resources of cellulose
Other biocompatible materials
Bamboo
Catalysts
Energy
New solar technology
New degradable wings
Transition to H
2
Even access globally
Transport
Carbon neutral transport
Less transport of goods
Weight reduction in transport
Energy saving technologies
 UFU, Alm.del - 2023-24 - Bilag 41: Præsentationer fra udvalgets forskningspolitiske studietur i Københavnsområdet ved Videnskabernes Selskab tirsdag den 20. februar 2024
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Chemistry in general education,
……………
just like reading and writing
A general education in chemistry :
Chemistry as positive fundamental science
Generally understand climate issues
Act responsibly in the political processes
Provide a better science based public debate
Control causes for corruption and political failures
Give chemistry more of the central role
Special thanks to
Christian Wenzel Tornøe, Klaus Bock, Mikael Bols
Danish National
consequences
Research Foundation
Individual
Carlsberg Laboratory
resource opportunities and limitations
Understand
Help share resources fairly in the world
University of Copenhagen
molecular level
Understand crafts at the
Masonry, bakery, food, construction, technology
Healthy life by understanding chemistry consequences
Phaedria M St Hilaire
Ajani O St Hilaire-Meldal
Anna Davolio Meldal
Sandra Davolio
meldal @ Chem.ku.dk