Sundhedsudvalget 2023-24
SUU Alm.del Bilag 163
Offentligt
2814323_0001.png
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0002.png
2
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0003.png
Table of Content
1. Introduction
2. Menopause – More Than Hot Flushes
3. Managing Menopause – Treatment Options
4. Clinical Guidelines for Menopause in the Nordic Countries
5. Women’s Encounter with the Healthcare Systems
6. What Impact Does Menopause Have – What Does Data Show?
7. Political Initiatives and Agreements
8. The Making of the Nordic Menopause White Paper
9. Sources
5
6
10
13
18
24
31
41
42
3
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0004.png
Reading Guide
The Nordic Menopause White Paper offers insights into menopause and its impact in
Sweden, Denmark, Finland, and Norway, exploring knowledge gaps and opportunities.
The first chapter
serves as an introduction, setting the context and outlining the aim of
the paper.
In the second chapter,
there is an explanation of menopause and its associated
symptoms.
The third chapter
describes the available treatment options for menopause, covering
both hormonal and non-hormonal approaches.
The fourth, fifth, sixth, and seventh chapters
explore the clinical guidelines
regarding menopause in the Nordic countries, women’s encounters with the healthcare
systems, existing data, and political initiatives and agreements addressing menopause.
Each of these chapters begins by defining its theme, then provides an overview of
insights from Sweden, Denmark, Finland, and Norway respectively. Following the
country-specific insights, gaps and opportunities are addressed.
The eighth chapter
briefly outlines the making of the Nordic Menopause White Paper.
Throughout the white paper, various cases are presented to showcase specific initiatives
related to menopause and to demonstrate the breadth of issues related to menopause.
A comprehensive list of references can be found at the end of the white paper.
4
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
1. Introduction
Menopause is not a disease but a natural phase of life. Given that half of the world’s population will
undergo this transition, addressing menopause and finding ways to enhance physical, mental, social,
and occupational health around menopause is highly relevant for individual women as well as for
workplaces and to society (1–3).
In the Nordic countries, nearly 1,7 million women fall between the ages of 45 and 54 years, the typical
age where most women experience menopause (4). About 20% of women experience minimal
menopausal symptoms, while the remaining 80% face symptoms of varying intensity (5). These
symptoms range widely, from hot flushes and night sweats to joint pains, mood swings, and sleep
disturbances. The list of possible symptoms is extensive. The physical and mental changes associated
with menopause are unique to each woman. The menopausal transition can be overwhelming,
liberating, or anything in between. Menopause is not confined to the private sphere. It takes place
everywhere and can impact every aspect of life. At home, at work, at social events, at the grocery store,
during the day and/or during the night. The transition can significantly influence quality of life, well-
being, and work capacity (1).
Women constitute almost half the workforce in the Nordic countries and are among the most
economically active in the world (6). In certain sectors such as healthcare, public services, and service
professions, women outnumber men. Therefore, understanding how the menopausal transition affects
women, their quality of life, and their ability to participate in the workforce is becoming increasingly
important (3,7,8).
The aim of this Nordic Menopause White Paper is to generate awareness about menopause by
providing an overview of current knowledge, data, and initiatives regarding menopause in the Nordic
countries covering Sweden, Denmark, Finland, and Norway. The objective is to uncover the gaps of
knowledge, data and political initiatives and spotlight the opportunities, challenges, and needs related
to menopause in the Nordics and in doing so initiate a cultural, societal, and political willingness to
improve the level of menopausal care and support at all levels.
5
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2. Menopause
– More Than Hot Flushes
Menopause marks the end of women’s reproductive years. This chapter of the menopause white paper
outlines menopause and the different symptoms that may be associated with the menopausal transition.
For most women, natural menopause is characterized by the cessation of monthly menstruation,
resulting from the loss of ovarian follicular function causing a decline in the circulation of blood
estrogen levels (9).
Natural menopause typically occurs between the ages of 45 and 55 years, marking a natural biological
progression. Menopause is determined retrospectively when 12 consecutive months without
menstruation have passed. However, some women experience menopause prematurely, occurring
between the age of 40 and 45 years. Premature menopause can be attributed to various factors,
including chromosomal abnormalities, autoimmune disorders, and other unknown causes. Surgical
procedures, such as the removal of both ovaries or medical interventions like radiation therapy and
chemotherapy, can also induce (premature) menopause (9).
It is not possible to predict when an individual woman will experience menopause though there
are some associations between the age of menopause and some health, genetic, and demographic
factors. The menopausal transition can be gradual, usually beginning with changes in the menstrual
cycle. The period leading up to menopause, known as perimenopause, can begin as early as the mid-
40s and persist for several years, with some women experiencing changes in their bodies even in their
mid-30s (9,10).
Symptoms related to the menopausal transition
The menopausal transition, driven by hormonal changes, can have a profound influence on various
facets of a woman’s health and well-being, encompassing physical, emotional, mental, and social
aspects. These changes can significantly affect a woman’s quality of life and her ability to work
(9,11). While the symptoms of the menopausal transition are highly individual, hot flushes and
sleep disturbances are the most common (12). Approximately 20% of women experience minimal
symptoms, while 80% grapple with symptoms to varying degrees (5).
6
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0007.png
Symptoms associated with menopause include (14):
Night sweats,
hot flushes, and
heightened body
odour
Mood swings,
irritability, panic
disorders, anxiety
and depression
Irregular
menstrual
cycle
Decreased
libido
Breast
soreness
Vaginal
dryness
Joint pain, muscle
aches and tension
and tingling hands
and feet
Headache, occasional
dizziness and fatigue
Changes in sense of
taste and burning
sensation in the
mouth
Bloating,
digestive changes,
and weight gain
Sensation of
electric shock
Sleep issues
Itchiness,
thinning hair
and brittle nails
Memory problems
and concentration
challenges
Loss of
bladder
control
Allergies
Irregular
heartbeat
Some of these symptoms are interconnected, while others are not. Some studies suggest that
symptoms may not always result directly from hormonal changes during the menopausal transition.
Instead, a ‘domino effect’ may occur, where one symptom triggers another. For example, night
sweats are sometimes believed to lead to sleep issues, and sleep problems, in turn, are associated
with irritability, fatigue, and difficulties with concentration (11). These interrelationships increase the
complexity and underscore the importance of health professionals, especially general practitioners,
possessing a high level of knowledge about menopause.
Other factors such as body composition and cardiovascular risk can also be affected by menopause.
The protective effects of estrogen that give women an advantage over men in terms of cardiovascular
diseases, gradually disappear as estrogen levels decline during menopause. Menopause can also
weaken pelvic support structures, increasing the risk of pelvic organ prolapse. Furthermore, the loss of
bone density during menopause contributes to an increased risk of fractures and a higher prevalence
of osteoporosis (9).
7
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
Case:
Books providing
knowlegde and
support
Across the Nordic countries, various health professionals, predominantly
gynaecologists, have authored books addressing menopause for women
navigating this transitional phase.
From Finland, “Virtaa vaihdevuosiin” (English: “Energy for Menopause”)
written by gynaecologist and clinical sexologist Leena Väisälä along with writer
Leeni Peltonen in 2020, comprehensively deals with menopause. This book
aims at breaking associated taboos by providing expert insights on hormone
functionality, treatments, lifestyle adjustments, and sexual well-being. Its primary
goal is to offer self-confidence and bring joy into this important phase of women’s
lives. Alongside expert knowledge, the book includes interviews with 33 Finnish
women aged 40-70, revealing what menopause signifies in the 21st century (16).
In Denmark, “Bogen om overgangsalderen” (English: “The Book About
Menopause”)
written by general practitioner Lotte Hvas in 2022 also seeks to
offer updated medical insights into menopause and what to anticipate. This book
aims to underscore that menopause is a natural aspect of women’s lives and a
phase that should neither be likened to an illness nor diminished (17).
The book “Hormonkarusellen” (English: “The Hormone Carousel”)
by
Swedish gynaecologist Hilde Löfqvist also explores menopause. The book
integrates scientific knowledge with over 30 years of professional experience,
outlining myths and facts about menopause and hormonal treatment (18).
From Norway, “Hetetokter & kalde fakta” (English: “Hot Flushes and Cold
Facts”)
written by gynaecologist Helena Enger outlines what to expect during
menopause. The book aims to empower women navigating the menopausal
transition (19).
The above books are examples and do not constitute an exhaustive list.
8
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0009.png
PROVIDING PERSPEC TIVE
The complexity of menopause calls for knowledge and support
The experience of menopause varies widely, leading to variability in individual experiences and
underlining the complexity of the field. Some studies suggest that in Western culture, menopause
is perceived as loss of sexual attractiveness, and potentially impacting mental health negatively
(14). Conversely, menopause can also be experienced as liberation from cultural limitations, offering
opportunities for personal development, and fostering feelings of competence and freedom (15). Thus,
addressing menopause necessitates a consideration of its complexity and variations.
This complexity places a substantial demand on both healthcare professionals who interact with
women experiencing menopausal symptoms and on women themselves, to recognize and address
their symptoms as needed. It underscores the need for knowledge, information, and support regarding
menopause among health professionals, women, workplaces, relatives, and the general public, as
recommended by the World Health Organization (WHO) (9).
9
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
3. Managing Menopause
– Treatment Options
There are a variety of interventions available to help alleviate the symptoms of menopause. The most
common form of treatment is hormonal treatment. Other treatment options include various medications,
non-hormonal moisturizers, and alternative approaches such as herbal medication, a healthy diet,
and physical activity. Throughout this chapter, an overview of the various treatment options related to
menopause is provided (12,20).
Hormonal treatment
Hormonal treatment stands as the most common intervention for addressing menopause-related
symptoms. Hormonal treatment replaces or supplements the female sex hormone, estrogens and
progestogens, that the body no longer produces in the same amounts. Estrogens are the primary
hormonal treatment for easing menopausal symptoms, while progesterons are typically recommended
for women with a uterus to prevent abnormal growth of cells in the inner lining of the uterus, the
endometrium, caused by estrogen. Women without a uterus do not need to take progesterone (21). There
are numerous hormonal treatment options on the market, each with different doses and forms (22,23):
Systemic, hormonal treatment:
Systemic hormonal treatment acts in the entire body and can be administered in various forms,
including tablets, gel, or spray.
Local treatment with estrogens:
This type of treatment acts locally in the vaginal mucous membranes. It is available in the form of
creams, suppositories, or estrogen-containing rings.
10
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0011.png
Non-hormonal treatment
Local treatments
There are moisturizers available that contain hyaluronic acid for vaginal use without hormones (5,24).
Systemic treatment
Medication
Different types of medication are also prescribed for menopausal symptoms. These includes some
types of antidepressants, including SSRI and SNRI, antiepileptic drugs, and antihypertensives (5).
Clinical guidelines provide information on these medications and there is some evidence of efficacy
for treatment of vasomotor symptoms. None of these medications have approved indications for the
treatment of menopausal symptoms (25). The European Medicines Agency is currently evaluating a
new non-hormonal treatment for hot flushes and night sweats (26).
Other types of treatment
In the last decade, complementary and alternative approaches to managing menopause have
become increasingly popular. These approaches encompass a wide range of botanic medicines,
physical activity, cognitive therapy, mindfulness, vitamin supplements, and dietary modifications. Data
regarding their effectiveness and safety are limited (27,28).
11
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0012.png
Navigating the complexity of menopause treatment
Treating menopausal symptoms is a highly personal and sometimes complex journey. The diverse
range of symptoms and their varying intensities underscore two needs. First, these symptoms
are actually recognized as being related to menopause by health professionals and hereby avoid
misdiagnosing women, wrong treatment and/or no treatment. Second, the need for different
treatment options. Deciding whether and how to treat menopausal symptoms requires guidance. This
brings attention to two essential points:
1.
2.
There is help and available treatments that can alleviate the symptoms of menopause.
There is a need for support and nuanced information for women facing menopause and general
practitioners. This will enable them to understand the available choices and make well-informed
decisions that match their requirements and needs.
Attitude towards Menopausal Hormonal Treatment
The use of hormonal treatment for menopausal symptoms has been a topic of ongoing
discussion among health professionals and menopausal women for decades.
In the early 2000s, the large epidemiological project “Women’s Health Initiative” from the
U.S. identified an association between the use of menopausal hormone therapy and the
risk of female cancers, particularly breast cancer, blood clots, and strokes (29).
Decades later, the initiative is now considered flawed due to several factors, such as
the age and health status of many participants, and the medications studied were not
the best suited to answer fundamental questions about the effectiveness of hormonal
therapies. The studies were not set up to investigate the effectiveness of hormone
replacement therapy on menopausal symptoms, but rather to determine if hormone
replacement therapy had beneficial effects on for instance the cardiovascular system.
Today the use of hormones is an ongoing discussion and guidelines are being updated
according to the latest scientific insights and findings (30).
In Denmark, the number of women using systemic hormonal treatment for menopausal
symptoms has decreased from almost 135,000 in 1999 to about 29,500 in 2022 (31).
In Sweden, one out of three women holds a negative attitude towards menopausal
hormone treatment (32). This, combined with a lack of knowledge, might lead women
to refrain from seeking advice and treatment from their general practitioner or local
healthcare center, resulting in missed opportunities for maximizing the benefits of
treatment for menopausal symptoms, as well as potential undertreatment.
12
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0013.png
4. Clinical Guidelines for
Menopause in the Nordic
Countries
Clinical guidelines play a pivotal role in healthcare, offering recommendations based on the best
available evidence for the care of individuals with specific conditions. In the context of menopause,
clinical guidelines aid healthcare professionals in making informed decisions and navigating the diverse
landscape of this life stage (33). This chapter provides an overview of current clinical guidelines on
menopause in the Nordic countries—Sweden, Denmark, Finland, and Norway.
Sweden has two distinct (clinical) guidelines on menopause.
The Swedish Medical Product Agency
The Swedish Medical Product Agency has made guidelines on menopause. The purpose of the
guidelines is to compile treatment recommendations that can be applied in primary care to offer
women an effective treatment of menopausal symptoms. According to the guidelines, about every
third woman experiences severe menopausal symptoms (vasomotor symptoms such as sweating, hot
flushes, and sleep problems) which require treatment (34).
Menopausal hormone therapy can be recommended to healthy women, younger than 60 years or
less than 10 years after menopause, with vasomotor symptoms that adversely affect their quality of
life. Women with an early menopause, before age 45, should be recommended menopausal hormone
therapy at least up to normal menopausal age. Menopausal hormone therapy can also be used to
prevent osteoporosis (34).
An individual benefit-risk assessment must be made prior to treatment, where the woman’s health
condition and the presence of any risk factors are considered. Contraindications to hormonal treatment
include known, previous or suspected breast cancer, known or suspected estrogen-dependent
malignant tumour (endometrial cancer), undiagnosed genital bleeding, untreated endometrial
hyperplasia, previous or ongoing venous thromboembolism (VTE), known thrombophilia diseases,
ongoing or recently gone through arterial thromboembolic disease, ongoing or previous liver disease
with not yet stabilized liver function values, and porphyria. Women with these contraindications should
not be prescribed hormonal treatment (34).
The guidelines from the Product Agency list treatment with estrogen (bioidentical estradiol), which
can be prescribed as a pill to be taken orally or as patches, gel, or spray to be used transdermal, as
well as progestogens to be taken sequentially or continuously with the estrogen, as endometrial
protection. A hormonal IUD can also be used as endometrial protection. The guidelines also mention
bioidentical progesterone as an alternative to the progestogens. However, there are yet no available
bioidentical progesterone with the indication as an addition to estrogen in Sweden. Although, “off
13
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0014.png
label” prescriptions of vaginal preparations figure, as well as license prescriptions of oral progesterone.
Combinations with dydrogesterone, which chemically speaking is like progesterone, has menopausal
symptoms as approved indication (34).
Other listed treatments for vasomotor symptoms, besides menopausal hormone therapy, are
antidepressants, physical activity, acupuncture, and herbal medicines. Besides vasomotor symptoms,
the guidelines also refer to urogenital issues, which are to be treated with local estrogen treatment (34).
The Swedish Society of Obstetrics and Gynaecology
In addition to the guidelines from the Swedish Medical Product Agency, the Swedish Society of
Obstetrics and Gynaecology (SFOG) made a guideline containing advice for menopausal hormone
treatment in 2019 (updated in 2021). The guideline is based on international guidelines but have
been adapted to fit the Swedish conditions. The guideline is very similar to the ones from the Swedish
Medical Product Agency (35).
The SFOG guideline states that it is the woman’s subjective menopause symptoms and experience
of how the symptoms affect her quality of life which determines whether she should be offered
treatment. The guidelines states that menopausal hormone therapy is the most effective and best
documented treatment for vasomotor symptoms and other estrogenic deficiency-related symptoms.
Menopausal hormone therapy also has positive effects on quality of life, sleep, bone mineral content,
fracture risk and, when inducted in close connection with menopause, also on cardiovascular disease,
diabetes, and total mortality (35).
In general, the guideline state that menopausal hormonal treatment must be individualized. One
should consider age, time of menopause, the woman’s health risks and preferences in assessing the
individual risk-benefit balance with menopausal hormone therapy. The physician should recommend
an appropriate menopausal hormone therapy formulation with the lowest effective estrogen dose and
optimal route of administration and offer the woman regular check-ups. Women who have their uterus
should be offered estrogen treatment combined with a progestogen (35).
Besides the more official national guidelines, “1177.se” and “Internetmedicin.se” are commonly
used online decision support tools for health care professionals and /or the public. However,
“internetmedicin.se” is a commercial website and not governmentally funded. The guidelines here are
also very similar to the ones from The Swedish Medical Product Agency and The Swedish Society of
Obstetrics and Gynaecology (36).
14
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0015.png
In Denmark, healthcare professionals can turn to “The Medical Handbook,” an official, digital
reference work, for a comprehensive description of menopause, including related symptoms,
treatments, and referrals (5).
Additionally, the Danish Health Authorities has defined menopause and
outlined hormonal treatment, including associated risks in their guideline. Non-hormonal treatment
options for hot flushes are briefly described. The article emphasizes that hormonal treatment with
estrogen or estrogen-progestogen combinations are the most effective options for hot flushes
compared to other treatments. It is recommended to limit hormonal treatment to the shortest duration
feasible, and the indication for treatment should be continuously evaluated (37).
The National List of Recommendations Denmark, updated in 2021, offers guidance on hormonal
treatment for climacteric and menopause in relation to urogenital symptoms, bleeding disorders, and
vasomotor symptoms. These recommendations support general practitioners in selecting suitable
medicines within a defined group of specific patients (38).
The Danish Association for Obstetrics and Gynaecologists provided clinical recommendations for
postmenopausal hormonal therapy. The guideline is from 2017 and is based on guidelines from the
National Institute for Health and Care Excellence (NICE). The recommendations encourage a three-
month trial of lifestyle interventions and cardiovascular risk assessment for women with moderate to
severe hot flushes. If lifestyle changes prove ineffective, tailored hormonal treatment may be initiated.
Notably, women at high risk for cardiovascular issues are not recommended for hormonal treatment.
The recommendations emphasize that hormonal substitution should only be considered for peri- and
early postmenopausal women but not after the age of 65 years (39).
The Danish Association for General Medicine does not provide specific guidelines on menopause. They do
offer guidelines from 2007 on gynaecological conditions, focusing primarily on bleeding disorders (40,41).
Finland does not have clinical guidelines for menopause (42). Instead, clinicians rely on the
Consensus Statement published in 2004, which outlines treatment practices.
This statement
resulted from the Women’s Health Initiative Research in 2002 (43). An initiative focusing on defining the
risks and benefits of strategies to reduce the incidence of heart disease, breast and colorectal cancer,
and fractures in postmenopausal women (44).
In June 2023, a working committee started preparing Current Care Guidelines for menopause. The
committee is facilitated by the Finnish Medical Society, Duodecim.
15
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0016.png
In Norway, guidelines on menopause are offered through the Norwegian Electronic Medical
Handbook, covering the diagnosis and treatment of menopause.
These guidelines are targeted
general practitioners and provide a straightforward overview of menopausal hormone therapy. They
were last updated in 2023 (23).
The Norwegian Association of Gynaecologists has also issued guidelines for menopause, targeted at
general practitioners. This guideline encompasses disturbances related to perimenopause, later stages
of menopause, symptoms throughout menopause, symptoms associated with induced menopause
and specified/unspecified disturbances. Hormonal treatment is addressed in these guidelines as
well. They were initially published in 2021 and are currently undergoing revision, with an expected
completion date of January 2024 (22).
General practitioners can also request Knowledge-based Update Visits (KUPP) on menopause, during
which they receive updated guidance on hormonal treatment. These visits are not mandatory but offer
a valuable resource for healthcare professionals (45).
Additionally, Helsenorge.no, a Norwegian website, provides information on menopause primarily
aimed at the public. The information includes a general guide to the various stages of menopause,
what symptoms to anticipate, and available treatment options. The information on Helsenorge.no does
not provide a comprehensive guide (20).
16
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0017.png
PROVIDING PERSPEC TIVE
Clinical guidelines focus on hormonal treatment
and lack holistic approach
In summary, clinical guidelines for managing menopause in the Nordic countries are predominantly
centered on hormonal treatment, with a primary emphasis on addressing hot flushes. This focus falls
short of capturing the multifaceted nature of menopause, which encompasses a broad spectrum of
physical, emotional, and mental changes. Despite the complexity of menopausal experiences, none of
the Nordic countries have established comprehensive, holistic guidelines on a national level, including
information to general practitioners about symptoms, treatment, and referral. Instead, guidelines are
presented in digital handbooks and by the gynaecological associations. Working groups in both Finland
and Norway have started to prepare new, updated guidelines on menopause.
Notably, Finland and Denmark lack guidelines specifically targeting general practitioners. In contrast,
Sweden has compiled guidelines that can be applied in primary care and Norway has established
guidelines and provides the option for general practitioners to request visits focused on menopause,
which may offer the general practitioners valuable insights and updates. Considering the complexity
and variability of menopausal experiences, it may be pertinent for Denmark and Finland to explore
the Norwegian and Swedish guidelines for general practitioners as a source of inspiration as well as
introducing visits focusing on menopause. It’s worth considering in all Nordic countries whether it
should be mandatory for general practitioners to have visits specifically addressing menopause. Lastly,
there could also be a potential value for the Associations of General Practitioners, especially Denmark
and Finland, to include menopause explicitly within their recommendations.
In short, there is a need for clinical guidelines that can provide essential support to healthcare
professionals, especially general practitioners, when encountering menopausal women. This is
essential to ensure that women have access to accurate, nuanced information and support during the
menopausal transition. Moreover, correctly diagnosing and providing optimal treatment is crucial to
women in the workforce, helping them maintain their functionality.
17
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0018.png
5. Women’s Encounter with the
Healthcare Systems
The menopausal transition is not a uniform experience. The extent and severity of symptoms vary,
as does the requirement for healthcare and support (11). This impacts women’s interactions with the
healthcare system. This chapter focuses on the women’s encounters with the healthcare systems
during the menopausal transition, highlighting existing gaps and opportunities for improvement.
Women often lack awareness of symptoms before seeking healthcare. While most women are aware of
symptoms like hot flushes and sweating, other menopausal symptoms are less familiar. Many women
are unprepared when they enter menopause, leading them to overlook the connection between their
symptoms and menopause. This affects their decision to seek healthcare and the potential outcomes
(32)
.
Regarding treatment, there are significant differences in women’s attitudes towards menopausal
hormone therapy. One out of three women holds a negative attitude towards hormonal treatment.
This, coupled with difficulties in accessing the correct support within healthcare, contributes to under-
treatment. Approximately one in three women experience severe menopausal symptoms that would
necessitate treatment, yet only 11% of women aged between 45 and 60 years received hormone
medication for menopausal symptoms prescribed by gynaecological care and primary care (32) .
Key aspects of women’s interactions with the healthcare systems
Almost half (44%) of the Swedish women going through menopause seek healthcare for
advice and/or treatment for their menopausal symptoms (32).
Depending on where women live in the country, the first instance of care will most likely be
either primary care/health centre or a gynaecologist clinic. Access to gynaecologists is notably
more straightforward if you reside in a major city area, particularly in Stockholm. Women visiting a
gynaecologist are more likely to be offered hormonal treatment compared to those who have visited a
health center/primary care (32).
There is widespread frustration among women going through menopause and healthcare
professionals due to the challenges in referrals between different care providers without receiving
what is perceived as adequate intervention. This frustration could be due to an insufficiently developed
chain of care within the local organization or inadequate recognition and response to menopausal
issues. Gynaecologist clinics possess greater knowledge on how to best support and treat women
going through menopause compared to primary care. At times, primary care misinterprets menopausal
symptoms as other conditions such as depression or fatigue/burnout (32,46–50).
18
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0019.png
In Denmark, women’s encounters with the healthcare system during menopause typically
adhere to the healthcare sector’s organizational structure.
Their initial point of contact is usually
their general practitioner, who also serves as a gatekeeper. General practitioners can refer women to
specialized practitioners, such as gynaecologists.
More than two-thirds of peri- and postmenopausal women have discussed menopause with a doctor,
either their general practitioner or another physician. Typically, these consultations evolve around
addressing menopausal symptoms, undergoing disease examinations, or receiving risk assessments.
In a Danish study from 2004 women have generally reported satisfaction with their medication or
examination needs, but concerns arose regarding risk assessments and information about menopause,
particularly the pros and cons of hormone therapy. Some women expressed a desire for more
information about alternatives to hormonal therapies (15,51).
In Denmark, private clinics that offer out-of-pocket consultations, treatments, and retreats focusing on
menopause are available, primarily in larger cities (52–54) .
In Finland, as high as 80% of menopause-related treatment begins with specialized care
provided by gynaecologists, with only 20% originating from healthcare professionals at local
public healthcare centres.
An even smaller percentage, 1-2%, begins with occupational health
physicians, who often refer women to gynaecologists (55).
Many women maintain long-standing relationships with a gynaecologist, with whom they have been
in contact during various stages of their lives and hereby are familiar with their individual health needs.
Specialised care predominantly concentrates in urban areas, while public healthcare centres are
more dominant in rural areas. There is a growing trend towards private health insurance that covers
consultations with specialists.
Due to the absence of clear clinical guidelines on menopause in Finland, healthcare professionals at
healthcare centres and occupational health physicians may experience uncertainty when diagnosing
and recommending treatment for menopausal symptoms. This uncertainty may be due to the variety
of menopausal symptoms, which also can overlap with other conditions, e.g., joint pain, depression, or
concentration challenges.
19
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0020.png
In Norway, women are often not consulted about menopause. They must ask themselves (22,56)
In larger cities, women with menopausal symptoms will often be referred by their general practitioner
to a gynaecologist. The largest cities have private gynaecologists who often have agreements with
public health care services. The hospitals in larger cities will refer women with menopausal symptoms
to private gynaecologists who have agreements with the public health system. In smaller cities, is it
often gynaecologists in public health system that treat women with menopausal symptoms.
Most patients will pay for hormone treatment out of pocket. Reimbursement can be granted after
individual applications if they fulfil certain criteria (23,58).
Case:
Menopause
awareness through
performance arts
In both Norway and Finland, menopause has been spotlighted in different
cultural formats, contributing to awareness about the transition.
Dora Thorhallsdottir in Norway has created a stand-up show dedicated
to menopause, offering insights into the various stages of this transition.
Through humour and relatable content, she raises awareness about the
experiences one can anticipate during menopause. Alongside her stand-up
show, Dora Thorhallsdottir also hosts a podcast, furthering her contributions to
menopause awareness (61).
In Finland, actress Anna Hultin presented the monologue play “Är det hett
här?” (“Is it hot here?”) at the Svenska Teatern in Helsinki. This monologue has
been performed over 50 times. Anna Hultin collected stories and emotions
from different Finnish women during six menopause evenings, showcasing the
challenges women face and expressing a newfound strength: “It is so wrong
how women can be treated. People of all ages are part of our community! I
have new strength to be me now” (62).
The performance arts serve as platforms for sharing personal experiences and
facilitating open conversations about menopause, thereby bringing attention
to the challenges (and opportunities) in this phase of life.
20
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
Case:
Women sharing
their menopausal
stories online
creating
community and
coherence
”Can a healthy person collapse in a year? I had not understood the multitude of
different symptoms, like heart palpitations, joint pain, melancholy, and trouble
sleeping”,
Finnish Salla Paananen
stated in an interview (57).
Alongside numerous Nordic women, Salla Paananen, shares her menopausal
journey openly in magazines, newspapers, TV segments, and through social
media. Through sharing her personal experiences, Salla Paananen aims to
raise awareness about menopause and address the lack of public discussion.
Menstruation, pregnancy, contraception, and childbirth are dealt with
through maternity care or school education programs, but where is the public
information about menopause? (57)
Norwegian midwife Anita Prante and primary physician Marianne
Natvik,
who is doing a Ph.D. project emphasizing women’s information needs
regarding menopause, are also vocal on both traditional media and social
platforms. Through their contributions and insights, they strive to bridge the
information gap about menopause (58) (59).
Danish influencer Annamette Fuhrmann
shares her menopausal transition
with her nearly 18,000 Instagram followers, expressing both the highs and
lows, providing tips, tricks, and personal insights. Fuhrmann actively engages
with her followers by encouraging questions, sharing stories, reposting
comments, and imparting knowledge about menopause (60).
In Sweden, Åsa Melin
hosts the largest podcast focused on female health,
called ‘Klimakteriepodden’ (English: ‘the Menopausal Podcast’). Across
numerous episodes, she, along with various guests, delves into various aspects
of the menopausal transition, exploring the physical and mental challenges, as
well as examining the level of knowledge within the healthcare system .
A common feature among the women sharing their stories is that they engage
with hundreds of other women, garnering significant responses for their
openness. This sharing of experiences not only contributes to the sharing
of knowledge but also fosters a community where women can connect,
exchange lived experiences, seek advice, and provide support to one another.
The examples shown represent a selection of women. Many other women in the
Nordic countries also publicly share their stories and experiences with menopause.
21
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0022.png
PROVIDING PERSPEC TIVE
22
Identifying gaps and opportunities for improvement
Navigating women’s journey through the Nordic healthcare systems when facing menopause is
challenging due to the complex and multifaceted nature of this phase. However, the key aspects of
women’s interactions with the Nordic healthcare systems indicate both gaps and opportunities for
improvement.
Existing gaps
Lack of information and knowledge:
Women are often not consulted about menopause. They must
ask themselves. However, this is challenged by the fact that as many as a every third women
state to lack knowledge of menopause and its implication for health and well-being. This affects
women’s possibilities in identifying menopausal symptoms and potentially their willingness
to seek healthcare and treatment even when needed (46–48). The lack of more holistic clinical
guidelines and support for general practitioners in managing menopause-related symptoms also
poses a significant concern.
Unequal health care:
Disparities in the distribution of specialist care, particularly gynaecologists,
between urban and rural areas as well as regional differences, might result in unequal access to
menopausal care and differences in what care is offered (32,48). Furthermore, private clinics with
user payments can also impact differentiated care between women who can afford the services
and those who cannot.
Undertreatment:
About a third of all menopausal women experience severe hot flushes and/or
night sweats, and could most likely benefit from treatment, particularly hormonal treatment – but
most of these women are not receiving treatment (32,48,49).
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0023.png
PROVIDING PERSPEC TIVE
Identified opportunities:
Information and guidelines for women:
All women should have access to accurate information
about menopause, available through various formats and from recognized sources, e.g. a brochure
that is proactively sent home or provided in connection with other healthcare visits, for example
during screening. Many women (of all ages) want information about the menopause. Mainly about
physical and psychological changes, what to expect, and actions to take. This can support women
to make informed decisions about treatment (46,50).
Support knowledge building for health professionals:
Health professionals, especially general
practitioners, should have a basic understanding of menopause and how to advise, support, and
treat women going through the menopausal transition whenever appropriate.
Menopause as an integrated part of women’s healthcare journey:
Addressing menopause needs
to be an integrated part of women’s healthcare journey, equivalent to other conditions such as
menstruation disturbances and pregnancy. To be able to offer interventions targeting different
symptoms of different degrees of severity, contributions from various perspectives and professions
are needed. If health centres/primary care are to be considered the first line of care for menopausal
symptoms, there needs to be well-functioning cooperation and communication with specialists,
gynaecological care, and clear pathways for referral when needed (32,46,48).
23
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0024.png
6. What Impact Does Menopause
Have – What Does Data Show?
Throughout history, there has been a notable absence of comprehensive research on menopause,
largely due to its perception as an inherent aspect of women’s daily challenges, something they simply
endure. Consequently, the available data and insights about menopause are sparse (1). However, some
research has been conducted and more is coming. This chapter examines existing data and research
from the Nordic countries regarding the menopausal transition.
National data on menopause from Sweden include a description of the efforts made to address
menopausal symptoms, a mapping of care and treatment of symptoms, statistical data on
conditions linked with menopause, and information and knowledge among women about
menopause.
Additionally, a report on sexual and reproductive health throughout life, including
menopause, was presented in 2022.
The National Board of Health and Welfare was given the task by the government to describe which
efforts are made considering menopausal symptoms in primary care and in the gynaecological
specialist care from an operational, professional, and patient perspective, as well as assess the need
for measures to improve advice, support, and treatment for patients with menopausal symptoms.
Over 2000 women aged 50-59 participated. Nearly all experienced menopausal issues, with 60%
facing moderate to severe hot flushes and sweating. Sleep problems, fatigue, mood swings, and
sexual complaints were also common. Many women lacked preparedness for menopause and sought
targeted information from healthcare. About a third had negative views on menopausal hormone
therapy (32).
A significant number sought advice from gynaecological clinics rather than primary care. Variations
in care quality and services were observed between different regions. The task force concluded that
there is a need for improved care coordination and better information dissemination, and primary care
should offer more interventions and act as a hub for menopausal symptom care, addressing physical,
psychological, and social aspects (32).
The National Board of Health and Welfare has also been tasked with mapping care and treatment of
menopausal symptoms from the perspective of equal care. This mapping aimed to understand care
patterns for menopausal symptoms. It examined healthcare data, revealing variations in care access
based on region and education level. Menopausal symptoms, such as hot flushes and dry mucous
membranes, affected many women. Findings included, that access to care varied: primary care was the
starting point in some regions, while others relied more on gynaecological care. Hormone medication
usage differed with education levels (48).
Evolution in treatment recommendations, prompted by health risks associated with hormonal drugs,
showcased the importance of knowledge-based care. New insights suggest reduced risks of certain
diseases with early hormone therapy. The focus remains on safe care with hormonal drugs (48).
24
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0025.png
Statistical data from the National Board of Health and Welfare’s statistical database from 2022
highlighted regional differences in specialized health care for menopausal conditions. It indicated easier
access in Stockholm compared to other regions. However, comparable data for primary care were
unavailable (63).
The Swedish Association of Local Authorities and Regions presented in 2022 a report that aimed
to address gaps in women’s sexual and reproductive health care. It emphasized the individuality of
menopausal experiences and symptoms affecting women’s quality of life, particularly hot flushes and
reduced sexual desire. The report stressed the need for better knowledge and tailored healthcare,
particularly for marginalized groups. Clear care paths and improved quality indicators are required (64).
Based on interviews with women aged 45-65 in Nordic countries, a report initiated by The Swedish
Association for Sexuality Education, RFSU, in 2022 showed that friends were the primary source for
discussing menopause, followed by partners. Many women lacked knowledge about symptoms other
than hot flushes and expressed a desire for more information, particularly self-care products available at
pharmacies (50,65).
Collectively the insights from the Swedish data and various reports highlight the need for improved,
individualized care, better information dissemination, and more accessible healthcare services tailored
to women’s diverse needs during menopause.
Case:
“Menopause
secured workplace”
at Apotek Hjärtat,
Sweden
Apotek Hjärtat in Sweden, like Partille kommun, has initiated efforts to enhance
awareness and understanding of how menopause can impact work life. In
2022, they conducted two extensive surveys, carried out by Kantar Public,
specifically focusing on menopause, with the latter survey placing additional
emphasis on menopause and its relationship to work life (77).
The surveys revealed that two out of three women (64%) reported
experiencing discomfort related to menopause, and one in four women (25%)
stated that it affected their professional lives negatively. The surveys also
indicated that over half (57%) admitted they have not reflected on whether
menopause-related problems have affected a colleague’s mood, well-being,
or job performance. Notably, this perspective was primarily shared by men
(64%) compared to women (49%). Only three percent stated that their current
employer has drawn attention to the menopause as a potential problem for
the colleagues who suffer from problems during the transitional age (77–79).
Based on the surveys, Apotek Hjärtat introduced an initiative to enhance the
working environment for women experiencing menopause, recognizing
that “menopause is not only a health issue – it is also a work environment
issue”. This included educating all managers at Apotek Hjärtat. Furthermore,
they have made this education available in both Swedish and English for
any company’s use (77,80). Therefore, the initiative aims not only to enhance
their internal operations but also to inspire other workplaces to improve and
become more inclusive.
25
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0026.png
During the early 2000s a series of studies focusing on menopause from the women’s
perspective was carried out in Denmark.
The studies emphasized women’s interactions with their general practitioners concerning menopausal
symptoms. The findings indicated that over two-thirds of menopausal women had discussions about
menopause with their general practitioners. Notably, it was predominantly the women who initiated
these discussions, seeking either treatment for menopausal symptoms, health examinations, or
risk assessments. While their medical and examination needs were met, there was a notable lack of
information provided about menopause (51).
Another focus of the studies was women’s positive experiences during menopause. Around half of
the women reported positive experiences, varying from general improvements in well-being to more
specific enhancements in relationships. The studies were based on a questionnaire answered by 972
randomly selected Danish women aged 51, along with in-depth interviews (15).
Presently, the most extensive project in a Danish context related to menopause is the ongoing
“Women in Healthy Transition.” The project, based at the University of Copenhagen, is designed to
create essential knowledge about menopause relevant for scientific understanding and beneficial
for women experiencing this phase of life (66). The first conclusions are expected to be presented in
2028 (1). The project has encountered challenges in securing funding and, as a result, has introduced
so-called crowdfunding to acquire necessary financial support. The researchers involved in the project
emphasize that securing research funds to support the field is challenging due to its perception as a
condition rather than a disease (2,67).
Additionally, an independent Danish consultancy conducted an analysis on women experiencing
menopause in the Danish labour market. The analysis, based on a questionnaire answered by 402
Danish women currently or previously going through menopause, revealed that a significant majority
faced symptoms impacting their work. Notably, 79% experienced sleeping problems, and 40%
encountered concentration difficulties. Only 3% reported discussing these issues with their immediate
supervisors at work (68).
The studies from the 2000s show that many Danish women turn to their general practitioners when
dealing with menopause, but they often do not receive sufficient information. However, as this data
is over 20 years old, the initiation of projects like ‘Women in Healthy Transition’ is crucial for expanding,
updating, and generating data and knowledge about menopause.
26
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0027.png
Finland has national data on menopause and its association with sleep during the menopausal
transition.
A 2013 Ph.D. study from the University of Turku revealed that menopausal women encountered more
sleep issues during workdays, experiencing difficulties falling asleep and more frequent awakenings at
night on weekdays compared to weekends and leisure time. Night awakenings were mostly attributed
to hot flushes and night sweats, primarily occurring in women who did not experience these symptoms
during the day. The study suggested that menopausal hormonal treatment might be more suitable
than sleeping pills for women going through this stage. The study involved 91 regularly working
women, using a 14-day sleep diary to compare sleep patterns between workdays and leisure time (69).
In 2021, the University of Turku presented a follow-up study on sleep during menopause. This study
involved 147 women as part of the larger “Women 46” project. Contradictorily, this study suggested
that the sleep of middle-aged women did not deteriorate over a ten-year span due to the menopausal
transition. The observed changes seemed to be more age-related than menopause-induced (70).
The disparity between the Ph.D. and the follow-up study underlines the necessity for further
investigation into the relationship between sleep and menopause. Especially since sleep is a prevalent
symptom of menopause, and sleep issues during workdays over an extended period can, among other
effects, impact the ability to work and levels of stress (71).
Case:
The Finnish
Menopause Society
In Finland, there exists a national society dedicated to menopause—the
Finnish Menopause Society. The society serves as a collaborative platform for
menopause researchers in Finland, establishing connections both locally and
internationally, and advancing menopause research. It was established to
facilitate discussions among specialists on various menopause-related issues.
To achieve this goal, the society organises scientific meetings, presentation
events, and seminars. Membership is open to all menopause researchers in
Finland, and individuals working towards the society’s objectives can also
join. The society’s main aim is to support, connect, and promote menopause
research initiatives in the country and beyond (76).
27
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0028.png
National data on menopause from Norway includes an ongoing Ph.D. project focusing on
women’s information needs during menopause and mapping the symptoms experienced
during the menopausal transition.
The results from the Ph.D. project from 2023 indicated that most women, at a median age of 45,
wished to receive information about menopause from their general practitioners to enhance their
quality of life. 67% of the women in the study desired information about menopause from their general
practitioner, and 62% sought information to ensure good future health (58).
The symptom mapping showed that one-third of the women experienced troublesome symptoms
related to menopause that affected their quality of life. Smoking was significantly associated with
experiencing more symptoms and an earlier onset of menopause (72).
In 2023 an expert group evaluated women’s health issues through all phases of life, including
menopause. The inquiry points to the fact that more focus on menopause will be beneficial both for
women, in this phase of their life, and society as a whole (73). Studies from the United Kingdom show
that women at the top of their career have complications in relation to menopause that cause them
to drop out of the workforce. The national inquiry shows that there is a great need for information
amongst general practitioners and women going through menopause so that they will receive better
advice and treatment that will help them better handle the changes in their bodies and lives (73).
Case:
Knowlegde-based
update visits in
Norway
The Norwegain campaign “Correct use of hormone therapy” by KUPP
(knowlegde-based update visits) was made in cooperation with RELIS (regional
drug information centers). The campaign was aimed at general practitioners
so that they would have access to updated information. The campaign’s
objective was to ensure that general practitioners would then be able to give
good advice and evaluations in relation to the use of hormone therapies for
women in menopause (45).
28
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0029.png
PROVIDING PERSPEC TIVE
More knowledge is needed – especially in Denmark,
Finland, and Norway
The menopausal transition holds relevance for many individuals, directly and indirectly impacting their
lives. Nevertheless, researchers highlight that it is shocking how little we know about this phase of life.
The available data and research from Danmark, Finland, and Norway reinforce the need for more insight
whereas Sweden can present insights on various aspects of menopause.
Insights from different institutions, including the National Board of Health and Welfare in Sweden, have
already highlighted multiple aspects of menopause. Through interviews, statistical data, and other
sources, Sweden has gained considerable insights, placing it notably ahead of other Nordic countries.
First, the amount of available data in Denmark, Finland, and Norway is sparse and there is not much
knowledge about women’s experiences during menopause. There is a significant gap in understanding
its effects on body image, identity, sexual drive, cognitive functions, relationships etc. as well as what
women can do to get through menopause and what treatment options they have.
Second, the existing data sets and studies include relatively small study populations, making it
challenging to draw comprehensive conclusions. This limitation contracts with the fact that half of the
population will experience menopause.
Third, the focus on menopause and its impact on women in the workforce is sparse in the Nordic
countries. Except for the independent analysis conducted in Denmark on menopause and its
correlation with the Danish labour market, research on the menopausal transition and occupational
health is significantly lacking, as well as an international study. The international study, as part of its
secondary objectives, has assessed work productivity among menopausal women experiencing
vasomotor symptoms. The study involved 836 women from Nordic countries and other parts of the
world. Data from the study indicates that approximately 30% of the participants reported no impact on
their work activities due to hot flashes or night sweats, and around 20% reported no impact on daily
activities (74).
Beside the analysis and the international study, this absence does not mean that there are no
challenges but rather highlights that there are almost no tools available for addressing menopausal
transitions in the context of work life. It is essential to recognize that the impact extends beyond the
individual woman, especially as more working women than ever before will undergo this phase. The
implications of a poor psychological work environment and increased sick days extend beyond the
individual woman, carrying substantial societal and economical costs (75).
Fourth, health professionals, particularly general practitioners, remain largely unaddressed in terms of
their knowledge levels about menopausal transitions and their need for further education and courses.
Understanding their perspectives and requirements for courses and education is also crucial.
29
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0030.png
PROVIDING PERSPEC TIVE
30
Inspiration for insights needed on menopause in the Nordic countries, especially Denmark,
Finland and Norway:
Women’s Perspective:
How do women experience menopause?
What are the effects on body image, identity, sexual drive, and relationships, etc?
What is the existing level of knowledge among women before entering menopause, and how can
this be improved?
Is the available information about menopause adequate, or does it need enhancement? If so, how
and where should it be accessible for women?
Well-educated Healthcare Professionals:
What is the current level of knowledge among general practitioners regarding menopause?
What is needed to elevate the level of knowledge and understanding of menopause, including
symptoms and treatment among general practitioners?
How can healthcare professionals, particularly general practitioners, best support women
experiencing the menopausal transition?
Menopausal Transition and Work Life:
To what extent does the menopausal transition affect working women and their work life?
Quantification of how menopause affects women’s economic participation.
How can workplaces better support employees going through the menopausal transition?
This comprehensive and holistic understanding is crucial to provide adequate support, education, and
resources for women experiencing menopause in the Nordic countries.
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0031.png
7. Political Initiatives and
Agreements
Political attention and the stance taken regarding menopause are of significant relevance, given the
potential impact on women’s health. This chapter is dedicated to examining the current political
initiatives and agreements (national, regional, and local) within the Nordic countries that specifically
target menopause.
Menopause and menopausal issues and symptoms are currently high on the political agenda in
Sweden.
This is clearly demonstrated through several political initiatives on national, regional, and local
levels. Besides political initiatives at these levels, it is also starting to become a subject for workplaces.
National level
On national level three larger initiatives have been initiated in 2022 and 2023.
First, the government has commissioned the National Board of Health and Welfare to carry out
initiatives for equal healthcare with a focus on diseases and conditions which mainly affects women
and girls, including specific conditions that relate to sexual and reproductive health like menopause.
The National Board of Health and Welfare is to submit their final report to the Ministry of Social Affairs
no later than March 31, 2026 (81–83).
Second, the so-called Tidö agreement (Tidöavtalet), between the government parties (the Moderate
Party, the Liberals, and the Christian Democrats) and the Sweden Democrats, mentions menopausal
symptoms as one area of focus. Under the headline “Equal health care as well as care and research
on women’s diseases and health”, one of the bullet points says, “Investing in care for migraines,
endometriosis, and menopausal symptoms” and menopausal symptoms are specifically mentioned
throughout the agreement. The government sees a need for special efforts for a more equal and
society-equal healthcare and has taken the initiative for a strengthened and extended investment
in maternity care and women’s health. The investment includes SEK 1.7 billion in 2023 and the
government expects to set aside a further SEK 1.5 billion annually in 2024 and 2025 (84–87).
Third, during the Swedish Parliament’s general motion period (September 12 - October 5, 2023), several
motions regarding menopausal care were submitted:
1.
2.
3.
Strengthened care for women in menopause (88)
Equal access to hormonal treatment (89)
Investing in research on women’s health and women-related diseases (90)
31
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0032.png
The first aims at reviewing the conditions for conducting a more equal and strengthened menopause
care. The second has three objectives; not letting Sweden fall behind in terms of hormone treatment
of menopause-related symptoms, equal accessibility to hormone treatment that affects our sex drive,
and the need for increased research and knowledge in menopausal care, i.e., regarding matters relating
to women’s sex drive, and announce this to the government. The third aims at strengthening research
and knowledge about women-related diseases with the aim of achieving equal care and announce this
to the government. The two first motions are to be processed by the social committee, and the third
motion is to be processed by the education committee (88–90).
Regional level
On a regional level two initiatives have been taken.
Sweden’s most southern region, Skåne, has established menopause clinics to tackle shortage of
gynaecologist appointments and that health centres/primary care do not always have the skills. These
clinics are midwifery clinics that have been tasked to specialize in advice and support for women going
through menopause. These midwife-led operations are not able to prescribe treatment, as midwives
do not have prescribing rights, but they have provided great support for many women. It also makes
it much easier for women to know where to seek their first instance of care when they are entering
menopause, or simply just have questions regarding menopause. It first started with 3 clinics in 2016,
and currently, there are 21 menopause clinics around the region (91–93).
Within Region Östergötland, the Health Care Board (HSN) helps develop care process programs
(vårdprocessprogram) for specific disease groups. The care process programs describe how the patient
group should be cared for and what is decisive for quality, including the responsibilities of the various
actors. Unlike most regional guidelines, the care process program regarding menopause in Region
Östergötland not only focuses on treatments but also the patient’s way through the healthcare system:
The board states: “Every year in Östergötland, roughly 2,000 women will suffer from menopause-
related issues, like hot flushes and sweating or urogenital problems. Some of these will seek healthcare
for this. There is a great need for correct information regarding menopause. Such information can
advantageously be made available via various actors in society, such as special interest associations
and pharmacies. The healthcare system has a responsibility to produce and maintain easily accessible
information about the state of knowledge that can be used by different actors” (94,95).
Local level
At local level, Partille municipality (Partille kommun) is the first in Sweden with a wellness initiative for
health during menopause. The ambition with the Partille wellness initiative is for the municipality’s
employees and managers to gain greater knowledge about menopause, and to be offered support
and help if they desire. The goal is for the employees to feel that the wellness initiative has helped them
feel better. As an employer, it is positive for the municipality to have employees who are well and thus
able to provide better service to the residents of Partille (96,97).
32
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
Case:
Initiatives beyond
the national,
regional, and local
levels in Sweden
In addition to the national, regional, and local initiatives other initiatives
focusing on menopause have been established in Sweden.
The Swedish Association of Health Professionals (Vårdförbundet), a trade union
and professional organization for nurses, midwives, biomedical scientists,
and radiographers, advocates for an expanded right of prescription for
midwives. They argue that “midwives’ prescribing rights should be extended.”
Despite working independently on numerous aspects, including menopausal
symptoms midwives lack authorization to prescribe certain drugs such as
estrogen (112–114).
Moreover, Lund University introduced a new course titled “Menopause
and Women’s Health,” which debuted in the spring of 2022. The first run of
the course received over 400 applicants vying for 40 available seats. This
digital course is accessible from anywhere and caters to various healthcare
professions encountering women experiencing menopause in their line of
work. The course covers a range of subjects, including normal physiological
changes, diverse treatment strategies, motivational speaking techniques,
women’s health from a global and sustainability perspective, and women’s
sexual health during menopause (115,116)
33
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0034.png
In Denmark, the focus on menopause remains notably scarce within the political landscape.
There is sporadic media attention, mainly highlighting individual stories from women experiencing
menopause. At a national or regional level, there are no political agreements addressing the
menopausal transition and its impact on women’s well-being, work life, and society. Neither the
Government, the Ministry of the Interior and Health, the Ministry of Employment, the Ministry of Social
Affairs, Housing and Senior Citizens nor associated authorities have presented specific initiatives, action
plans, or agreements focusing on menopause (98–103). However, in the 2024 agreement concerning
the allocation of research reserve, there is a specific emphasis on female health and the disparities
in health between men and women. This focus area falls within the framework of strengthened and
independent research (104).
Currently, Denmark has no legislative frameworks concerning the rights and obligations related to the
different stages in women’s lives, encompassing menstruation and menopause and the associated
symptoms. As a result, any initiatives within Danish workplaces are voluntary. Pending potential
legislation in this area, it can potentially serve as a competitive advantage for companies to distinguish
themselves and become more appealing when attracting and retaining labour (105).
Case:
Let’s talk about
menopause
The LEGO Group has in 2023 introduced a menopause program for its
employees, “Let’s talk about menopause”. This initiative aims to build greater
awareness among all LEGO employees and establish secure spaces within
the workplace for open conversations about well-being. By raising awareness
about menopause and extending support, LEGO is committed to remove the
stigma associated with discussing menopause at work. The goal is to provide
colleagues the necessary support while acknowledging the significance of
fostering inclusive and diverse workplaces.
“This program is dedicated to educating everyone about a topic that,
traditionally, many have felt uncomfortable discussing in a professional setting.
Through this educational initiative, the aim is to support colleagues as they
navigate through this significant stage of life” - Loren I. Shuster, Chief People
Officer and Head of Corporate Affairs at LEGO.
The program was launched in May 2023 in the United Kingdom and is
scheduled to extend to Denmark and Singapore later in 2023 (119).
34
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0035.png
In Finland, there is no political initiative or agreement regarding menopause at national or
regional level.
However, in 2023, the recognition of menopausal symptoms as a factor influencing
functionality at work was included in the Government Programme for 2023-2027: “The identification
of menopausal symptoms and good treatment in occupational healthcare will be promoted to
strengthen wellbeing and reduce misdiagnosis and sickness absences” (106)
On a local level, Maija Kajan, a gynaecologist and former member of the Tampere city council, put forth
an initiative in 2019 to establish a service point for menopause in Tampere’s public health care. This
service point was intended for both women and men but faced rejection, seemingly due to economic
constraints (107). Maija Kajan is no longer active in politics but has a private practice and authored
several books and blogs on menopause (108).
In 2023, a national public inquiry, Kvinnehelseudvalgets NOU 2023:5, specifically focused on
women’s health throughout all phases of life, including menopause.
An expert group conducted
this national political initiative, resulting in 75 concrete recommendations or actions, two of which
were directed towards menopause (73).
The recommendations included expanding the options for hormone therapy reimbursement
during menopause and enhancing knowledge about menopause in the context of the working
environment (73). A national health and cooperation plan, anticipated to be unveiled in December
2023, is expected to incorporate many issues mentioned in the public inquiry, aiming to ensure
equal treatment opportunities across all regions of Norway (109). A unanimous parliament asked the
government during the speech from the throne, to ensure that women’s health becomes a central part
of the national health and cooperation plan, and that concrete proposals for measures and a plan are
presented in it (110).
A women’s health strategy, based on the public inquiry, is scheduled to be introduced in early 2024,
but it remains uncertain which menopause-related elements will be integrated into this strategy.
There is general increased political awareness around women’s health in Norway and hereunder
menopause. On the 18th of October a question was raised in Parliament by Sandra Bruflot, women’s
political spokesperson for the Conservative party, about women’s health and menopause. The question
was directed towards the Health and Care Minister as to why the further work with the national inquiry
on women’s health was not an open political process, and why the Minister considered a strategy
sufficient (111). Apart from this latest question, women’s health is a regular political theme that is
gaining more and more traction.
35
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
Case:
Women’s Health
Alliance in Norway
The Women’s Alliance (Kvinnehelsealliansen), the Norwegian Women’s Public
Health Association (Norske Kvinners Sanitetsforening) in collaboration with
several patient organisations focusing on women’s health concerns.
The alliance has taken a central role in advocating for women’s health and is
actively pushing for a white paper on the National inquiry into women’s health.
They have been vocal through demonstrations, urging for significant political
reforms and policy changes.
The alliance continues to pressure the political system, addressing a wide array
of women’s health aspects (117).
36
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
Case:
Growing
emphasis on
menopause
in the United
Kingdom
In the United Kingdom, there has been an increasing focus on menopause.
In July 2021, initiated by the British Secretary of State for Employment, various
organisations were tasked with examining the significance of menopause
concerning women’s work lives. An independent report resulting from
this inquiry was published in November 2021. This report outlined 10 key
recommendations aimed at introducing changes and providing support for
women experiencing menopause in multiple spheres, including government
policies, the labour market, societal aspects, and financial considerations.
These recommendations proposed elevating the priority of menopause
in employment-related policies and fostering diversity, as well as creating
methodologies to assess the costs of menopause for individuals, workplaces,
and the UK economy (3).
The NHS Taking the Lead
Furthermore, the British health sector, the National Health Service (NHS), has
taken a leading role in adapting workplaces to support women navigating
through menopause, particularly as women constitute 77% of the 1.3 million
people constituting the NHS workforce.
In 2021, the NHS initiated the “Menopause Pathway Improvement Programme,”
designed to bring together experts in the field and other key stakeholders
to enhance the clinical treatment of menopause in England. This program
is structured around two primary components: First, developing treatment
pathways aligned with NICE guidelines, and second, implementing a retention
strategy for the NHS workforce. Additionally, the programme involves a
public health campaign to raise awareness of symptoms, challenge stigmas,
and provide guidance on where women experiencing symptoms can seek
assistance (3,118).
37
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0038.png
PROVIDING PERSPEC TIVE
38
Now is the time for increased political action regarding
menopause
Menopause stands as a significant life event that all women will undergo, but each woman experiences
it uniquely. It marks a natural transition wherein both the body and mind undergo changes. This phase
can significantly impact various aspects of life and well-being. And menopause occurs at a time when
women are in the midst of their careers. At a time where women across the Nordic countries are
openly sharing their individual experiences with menopause, with female health gaining prominence
on the political agenda, there exists a crucial opportunity for increased political awareness and action
regarding the topic of menopause across all Nordic countries.
Examining the current landscape of political agreements and initiatives addressing menopause in the
Nordic countries reveals a general lack of political attention in Denmark and Finland. Denmark and Finland
are lacking any dedicated initiatives targeting menopause. Norway has taken steps at the national political
level toward addressing women’s health during menopause and women’s health in general is a topic
that is receiving greater and greater amount of political attention. Norway’s recommendations even
acknowledge the impact of the menopausal transition on work life. Specific political actions are under
development. On the other hand, in Sweden, there is a growing political awareness of the menopausal
transition across national, regional, and local levels. The attention within Swedish politics is generating
momentum for action and urging the same in Denmark, Finland, and Norway.
The question of whether there is a correlation between the limited political focus, particularly in
Denmark and Finland, and the absence of data, research, and knowledge about menopause in the
Nordic countries, remains a topic of debate. Nonetheless, the lack of attention contrast the significant
impact on individual women’s well-being, as highlighted by personal stories shared in the media and
across social platforms.
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0039.png
PROVIDING PERSPEC TIVE
39
This lack of attention also sharply contrasts with the potential effects menopause can have on work life
and its broader implications for the workforce and the economy. If more women remained in workforce
and worked for longer, retaining higher-paid roles, it could benefit the economy and society in Nordic
countries through increased productivity and income tax contributions (3). There is limited knowledge
regarding the frequency of sick leave, job terminations, and decreased productivity resulting from
symptoms related to the menopausal transition. As a result, there is minimal knowledge about how
menopause affects women’s workplace participation and the economy in the Nordic countries. In
the United Kingdom, this issue led to a government-initiated working group suggesting the need to
develop a methodology to measure the costs of menopause on individuals, work life, and the economy.
Similar initiatives in the Nordic countries could serve as a basis for acquiring knowledge and guide
political decision-making (3).
The Nordic countries have a unique opportunity to draw inspiration from the ongoing menopause
movement in the United Kingdom. In the UK, attention and initiatives addressing menopause have
notably increased over the last decade, resulting in political mandates and specific action plans, such
as those within the National Health Service (NHS). These plans aim to improve treatment pathways,
introduce retention strategies, and launch public health campaigns focused on understanding
and navigating the menopausal transition. The progress made in the United Kingdom can serve as
a valuable model for initiating similar initiatives and strategies in the Nordic countries, ultimately
benefiting women’s well-being and occupational health.
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0040.png
KRUSE
LARSEN
40
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
8. The Making of the Nordic
Menopause White Paper
The Nordic Menopause White Paper represents a collaborative effort across the Nordic countries,
involving four consultancies: Reform Society (Sweden), Ahjo Communications Oy (Finland), Kruse
Larsen (Norway), and Molecule Consultancy (Denmark).
Each consultancy has collected and reported country-specific data on menopause, covering clinical
guidelines, treatment options, national data, and political agreements and initiatives related to
menopause (national, regional, and local). Additionally, all consultancies have contributed with various
case studies that are integrated throughout the white paper.
The data was gathered through desk research and reviewing relevant literature about menopause as
well as conversations with health professionals, mainly gynaecologists. Based on the country-specific
data, Molecule Consultancy has written and formatted the white paper.
The Nordic Menopause White Paper is made with financial support from Astellas Pharma.
41
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
9. Sources
1.
2.
3.
Dalgas J. Nyt stort studie skal undersøge overset periode i kvinders liv: Alle kvinder kommer til at opleve det. 2023 Apr 15;
Skarum S. Politiken . 2023 [cited 2023 Oct 29]. Forskere går nye veje for at belyse tabubelagt overgangsalder. Available from: https://politiken.
dk/indland/art9216764/Forskere-g%C3%A5r-nye-veje-for-at-belyse-tabubelagt-overgangsalder
Department for Work & Pensions. Policy paper: Menopause and the Workplace: How to enable fulfilling working lives [Internet]. 2022 Jul [cited
2023 Oct 29]. Available from: https://www.gov.uk/government/publications/menopause-and-the-workplace-how-to-enable-fulfilling-work-
ing-lives-government-response/menopause-and-the-workplace-how-to-enable-fulfilling-working-lives-government-response
Globalis. Lande [Internet]. 2023 [cited 2023 Oct 30]. Available from: https://www.globalis.dk/Lande
Trolle D, Søndergaard A. Klimakteriet [Internet]. 2021 [cited 2023 Oct 25]. Available from: https://www.sundhed.dk/sundhedsfaglig/laege-
haandbogen/gynaekologi/tilstande-og-sygdomme/diverse/klimakteriet/
Nordic Co-operation. norden.org. [cited 2023 Oct 31]. 10 facts about gender equality. Available from: https://www.norden.org/en/informa-
tion/10-facts-about-gender-equality
UNAIDS. The Gap Report [Internet]. 2014 Jul [cited 2023 Oct 30]. Available from: https://www.unaids.org/sites/default/files/media_asset/12_
Peopleaged50yearsandolder.pdf
Larsen M, Holt H, Larsen MR. Et kønsopdelt arbejdsmarked [Internet]. 2016 [cited 2023 Oct 30]. Available from: https://pure.vive.dk/ws/
files/466934/1615_Et_k_nsopdelt_arbejdsmarked.pdf
World Health Organization. Menopause, Key facts [Internet]. 2022 [cited 2023 Oct 25]. Available from: https://www.who.int/news-room/fact-
sheets/detail/menopause
4.
5.
6.
7.
8.
9.
10. Redaktionen. Perimenopause, menopause og postmenopause – overgangsalderens tre faser [Internet]. 2019 [cited 2023 Oct 25]. Available
from: https://menopause.dk/perimenopause-menopause-og-postmenopause-overgangsalderens-tre-faser/
11. Brewis J, Beck V, Davies A, Matheson J. The effects of menopause transition on women’s economic participation in the UK. 2017 Jul.
12. Tiitinen A. Duodecim Terveyskirjasto. 2023 [cited 2023 Oct 25]. Vaihdevuodet. Available from: https://www.terveyskirjasto.fi/dlk00179
13. National Institute on Aging. What Is Menopause? [Internet]. 2021 [cited 2023 Oct 25]. Available from: https://www.nia.nih.gov/health/
what-menopause
14. Obermeyer CM. Menopause Across Cultures: A Review of the Evidence. The Journal of The Menopause Society . 2000;7(3):184–92.
15. Hvas L. Menopausal women’s positive experience of growing older. Maturitas. 2006 Jun;54(3):245–51.
16. Väisälä L, Peltonen L. Virtaa vaihdevuosiin. Otava ; 2020.
17. Hvas L. Bogen om overgangsalderen. 2nd ed. Kiim; 2022.
18. CDON. Hormonkarusellen : fakta och myter om klimakteriebehandling [Internet]. 2023 [cited 2023 Nov 6]. Available from: https://cdon.dk/
boger/hormonkarusellen-fakta-och-myter-om-klimakteriebehandling-c109789151927763
19. CDON. Hetetokter & kalde fakta [Internet]. 2023 [cited 2023 Nov 6]. Available from: https://cdon.dk/boger/helena-enger/hetetokter-kalde-fak-
ta-54503031
20. helsenorge.no. Overgangsalder: Hva er det? [Internet]. 2020 [cited 2023 Oct 25]. Available from: https://www.helsenorge.no/sykdom/underliv/
menopause/
21. NHS.uk. Types of hormone replacement therapy (HRT) [Internet]. 2023 [cited 2023 Nov 14]. Available from: https://www.nhs.uk/medicines/
hormone-replacement-therapy-hrt/types-of-hormone-replacement-therapy-hrt/
22. Øverlie I, Ullern ÅM, Johansen N. Overgangsalder (menopause) [Internet]. 2021 [cited 2023 Oct 25]. Available from: https://www.legeforenin-
gen.no/foreningsledd/fagmed/norsk-gynekologisk-forening/veiledere/veileder-i-gynekologi/overgangsalder-menopause/
23. Barlindhaug SF. Overgangsalder (klimakteriet) [Internet]. 2023 [cited 2023 Oct 25]. Available from: https://legehandboka.no/handboken/klini-
ske-kapitler/gynekologi/tilstander-og-sykdommer/ulike-sykdommer/klimakteriet
24. Stute P. Is vaginal hyaluronic acid as effective as vaginal estriol for vaginal dryness relief? Arch Gynecol Obstet. 2013 Dec 1;288(6):1199–201.
25. Swedish Medical Products Agency. Läkemedel vid klimakteriesymtom, menopausal hormonbehandling (MHT) – behandlings¬rekommenda-
tion [Internet]. 2022 [cited 2023 Oct 31]. Available from: https://www.lakemedelsverket.se/sv/behandling-och-forskrivning/behandlingsrekom-
mendationer/sok-behandlingsrekommendationer/lakemedel-vid-klimakteriesymtom-menopausal-hormonbehandling-mht--behandlingsre-
kommendation#hmainbody1
26. European Medicines Agency. Veoza [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.ema.europa.eu/en/medicines/human/
summaries-opinion/veoza
27. Taylor M. Complementary and Alternative Approaches to Menopause. Endocrinol Metab Clin North Am. 2015 Sep;44(3):619–48.
28. Daley A, Stokes-Lampard H, Thomas A, MacArthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2014;11.
29. University of Oxford. The Million Women Study: design and characteristics of the study population. Breast Cancer Research. 1999 Dec 1;1(1):73.
30. Cetel MD N. Women’s Health Initiative: Landmark Study or Landmine? Worth. 2023 Mar 23;
42
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
31. Sundhedsdatastyrelsen. MEDSTAT.dk [Internet]. 2023 [cited 2023 Nov 14]. Available from:
https://medstat.dk/da/viewDataTables/medicalTreatments/%7B%22year%22:%5b%222022%22,%222021%22,%222020%22,%222019%22,%
222018%22,%222017%22,%222016%22,%222015%22,%222014%22,%222013%22,%222012%22,%222011%22,%222010%22,%222009%22,
%222008%22,%222007%22,%222006%22,%222005%22,%222004%22,%222003%22,%222002%22,%222001%22,%222000%22,%221999%22,%
221998%22,%221997%22,%221996%22%5d,%22region%22:%5b%220%22%5d,%22gen-
der%22:%5b%222%22%5d,%22ageGroup%22:%5b%2245-64%22%5d,%22searchVariable%22:%5b%22people_count%22%5d,%22error
Messages%22:%5b%5d,%22treatmentGroup%22:%5b%22OeMs%22%5d%7D
32. Socialstyrelsen. Vård och behandling vid klimakteriebesvär i primärvården samt i den gynekologiska specialistvården [Internet]. 2021 Sep [cited
2023 Oct 31]. Available from: https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/ovrigt/2021-9-7583.pdf
33. The Danish Health Authorities. Kliniske anbefalinger og retningslinjer [Internet]. 2023 [cited 2023 Oct 25]. Available from: https://www.sst.dk/
da/viden/sundhedsvaesen/nkr-og-nka
34. Swedich Medical Products Agency. Menopausal hormone therapy (MHT) - treatment recommendation [Internet]. 2022 [cited 2023 Oct 31].
Available from: https://www.lakemedelsverket.se/en/treatment-and-prescription/behandlingsrekommendationer/sok-behandlingsrekom-
mendationer/menopausal-hormone-therapy-mht---treatment-recommendation#hmainbody1
35. Svensk förening för Obstetrik och Gynekologi (SFOG). Svensk förening för Obstetrik och Gynekologi (SFOG) [Internet]. 2023 [cited 2023 Oct 31].
Available from: https://www.sfog.se/start/
36. 1177.se. Klimakteriet [Internet]. 2023 [cited 2023 Nov 10]. Available from: https://www.1177.se/liv--halsa/sa-fungerar-kroppen/klimakteriet/
37. Andersen LB, Schroll JB, Horwitz H, Løkkegaard E, Hvas L. Hormonbehandling i overgangsalderen. Rationel Farmakoterapi [Internet]. 2022 Apr 6
[cited 2023 Oct 25];3. Available from: https://www.sst.dk/da/udgivelser/2022/Rationel-Farmakoterapi-3-2022/Hormonbehandling-i-overgang-
salderen
38. Den Nationale Rekommandationsliste. Hormonbehandling i klimakterie og menopause . 2021.
39. Aaen TB, Arentoft B, Hennings LI, Nielsen SK, Schroll J, Sjögren LL, et al. Postmenopausal hormonterapi med udgangspunkt i NICE guide-
line [Internet]. 2017 [cited 2023 Oct 25]. Available from: https://static1.squarespace.com/static/5467abcce4b056d72594db79/t/59419ba-
f725e253851a0be64/1497471926097/CVD_HT_endelige_EL_LH+%281%29.pdf
40. DSAM the DA for GM. Blødningsforstyrrelser hos kvinder i almen praksis [Internet]. [cited 2023 Oct 25]. Available from: https://content.dsam.
dk/guides/vejlednings-pdf/pp_bloedning_final_200608.pdf
41. DSAM TDA for GM. Blødningsforstyrrelser hos kvinder i almen praksis [Internet]. 2007 [cited 2023 Oct 25]. Available from: https://www.dsam.
dk/vejledninger/bloedningsforstyrrelser
42. The Finnish Medical Society Duodecim. Current Care Guidelines are independent, evidence-based clinical practice guidelines [Internet]. 2023
[cited 2023 Oct 25]. Available from: https://www.kaypahoito.fi/en/
43. Suomalainen Lääkäriseura Duodecim. KONSENSUSLAUSUMA [Internet]. 2004 Nov [cited 2023 Oct 25]. Available from: https://www.duodecim.
fi/wp-content/uploads/sites/9/2016/02/lausuma_02122004.pdf
44. Writing Group for the Women’s Health Initiative Investigators. Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Wom-
en: Principal Results From the Women’s Health Initiative Randomized Controlled Trial. JAMA: The Journal of the American Medical Association.
2002 Jul 17;288(3):321–33.
45. Langaas HChr. KUPP-kampanje om hormoner i overgangsalderen [Internet]. 2021 [cited 2023 Oct 25]. Available from: https://relis.no/artikler/
nyheter/ny-kupp-kampanje-om-hormoner-i-overgangsalderen-2/
46. Lycke A, Brorsson A. Swedish women’s experiences of menopausal transition: A focus group study. Sexual & Reproductive Healthcare. 2023
Mar;35:100807.
47. Schlein S. Jenny, 52: Chefer måste börja prata om klimakteriet [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.sydsvenskan.
se/2023-05-10/jenny-52-chefer-maste-borja-prata-om-klimakteriet
48. Socialstyrelsen. Kartläggning av vård och behandling vid klimakteriebesvär ur perspektivet jämlik vård [Internet]. 2020 Feb [cited 2023 Oct 31].
Available from: https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/ovrigt/2020-1-6568.pdf
49. Karolinska Institutet. ”Obefogad rädsla ska inte hindra behandling” [Internet]. 2022 [cited 2023 Oct 31]. Available from: https://ki.se/forskning/
obefogad-radsla-ska-inte-hindra-behandling
50. RFSU. Ny rapport från RFSU: Oroande låg kunskap om klimakteriet i Sverige – få kvinnor söker kunskap hos vården [Internet]. 2023 [cited 2023
Oct 31]. Available from: https://www.rfsu.se/om-rfsu/press/pressmeddelanden/2023/ny-rapport-fran-rfsu-oroande-lag-kunskap-om-klimakter-
iet-i-sverige--fa-kvinnor-soker-kunskap-hos-varden/
51. Hvas L, Reventlow S, Malterud K. Women’s needs and wants when seeing the GP in relation to menopausal issues. Scand J Prim Health Care.
2004 Jun 12;22(2):118–21.
52. MenopauseKlinikken. Menopauseklinikken.dk [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://menopause-klinikken.dk/
53. Chandra Yoga. Yoga og overgangsalder [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://chandrayoga.dk/yoga-overgangsalder/
54. Menokonsult. Menokonsult.dk [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://menokonsult.dk/
55. Kela. Kela [Internet]. 2023 [cited 2023 Nov 14]. Available from: https://www.kela.fi/main-page
56. Natvik M, Gjelsvik B, Vangen S, Skjeie H, Brekke M. Women’s information needs about menopause: a cross-sectional survey in Norwegian gener-
al practice. BJGP Open. 2023 Sep 5;BJGPO.2023.0127.
57. Kotiliesi. Salla Paajanen avautuu vaihdevuosista: “mietin voiko terve ihminen romshtss vuodessa” [Internet]. 2019 [cited 2023 Oct 30]. Available
from: https://kotiliesi.fi/ihmiset-ja-ilmiot/salla-paajanen-avautuu-vaihdevuosista-mietin-voiko-terve-ihminen-romshtss-vuodessa/
43
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
58. Natvik M, Gjelsvik B, Vangen S, Skjeie H, Brekke M. Women’s information needs about menopause: a cross-sectional survey in Norwegian gener-
al practice. BJGP Open. 2023 Sep 5;BJGPO.2023.0127.
59. Prante A. Menopause by Anita [Internet]. 2023 [cited 2023 Oct 30]. Available from: https://www.menopausebyanita.com/
60. Fuhrmann A. @fuhrmannshedetur [Internet]. Instagram . 2023 [cited 2023 Oct 30]. Available from: https://www.instagram.com/fuhrmannshe-
detur/?hl=da
61. dorathorhallsdottir.no. Overganger [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://dorathorhallsdottir.no/
62. iltalehti.fi. Annan sydän hakkasi, väsytti ja jalkapohjatkin sattuivat – Vasta vuosien kuluttua oireiden syy selvisi [Internet]. 2023 [cited 2023 Oct
29]. Available from: https://www.iltalehti.fi/terveysuutiset/a/f05604ca-81a3-4ee1-a2cf-052c2f254bd6
63. The National Board of Health and Welfare. Statistical databases [Internet]. 2019 [cited 2023 Oct 31]. Available from: https://www.socialstyrelsen.
se/en/statistics-and-data/statistics/statistical-databases/
64. Sveriges Kommuner och Regioner. Kvinnors sexuella och reproduktiva hälsa genom livet [Internet]. 2022 [cited 2023 Oct 31]. Available from:
https://skr.se/download/18.542a096a18019210a486453/1649764736293/Kvinnors-sexuella-och-reproduktiva%20h%C3%A4lsa%20genom%20
livet.pdf
65. RFSU. RFSU Klimakteriekollen [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.rfsu.se/globalassets/pdf/rfsu-klimakteriekol-
len-2023.pdf
66. Nexs. Kvinder i Sund Overgang (KISO) [Internet]. [cited 2023 Oct 29]. Available from: https://nexs.ku.dk/forskning/idraet-individ-samfund/sorse/
kiso/
67. Nexs. Støt forskning i kvinders overgangsalder via crowdfunding [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://nexs.ku.dk/nyhed-
er/2023-nyheder/stoet-forskning-i-kvinders-overgangsalder-via-crowdfunding/
68. Menokonsult. Undersøgelse af kvinders overgangsalder på det danske arbejdsmarked [Internet]. 2023 Sep [cited 2023 Oct 29]. Available from:
https://menokonsult.dk/wp-content/uploads/2023/09/Undersoegelse-af-kvinders-overgangsalder-paa-det-danske-arbejdsmarked.pdf
69. Kalleinen N, Aittokallio J, Lampio L, Kaisti M, Polo-Kantola P, Polo O, et al. Sleep during menopausal transition: a 10-year follow-up. Sleep. 2021
Jun 11;44(6).
70. Lampio L, Saaresranta T, Polo O, Polo-Kantola P. Subjective sleep in premenopausal and postmenopausal women during workdays and leisure
days. Menopause. 2013 Jun;20(6):655–60.
71. Jennum P, Bonke J, Clark AJ, Flyvbjerg A, Garde AH, Hermansen K, et al. Søvn og sundhed . København ; 2015.
72. Gjelsvik B, Rosvold EO, Straand J, Dalen I, Hunskaar S. Symptom prevalence during menopause and factors associated with symptoms and
menopausal age. Results from the Norwegian Hordaland Women’s Cohort study. Maturitas. 2011 Dec;70(4):383–90.
73. Regjeringa. NOU 2023: 5 Den store forskjellen — Om kvinners helse og betydningen av kjønn for helse [Internet]. 2023 [cited 2023 Oct 29].
Available from: https://www.regjeringen.no/no/dokumenter/nou-2023-5/id2964854/
74. Astellas. Prospective Survey of Women with Vasomotor Symptoms Associated with Menopause in Nordic Europe, Canada, Brazil and Mexico
- WARM Study. 2022 [cited 2023 Nov 14]; Available from: https://s3.amazonaws.com/ctr-ast-7491/2693-MA-3235/15a46461-00b6-4cad-8e49-
5ac2e9b38fcb/a5a89605-43f5-461f-bb9d-36ce4c954b12/2693-ma-3235-abstract-disclosure-redacted-v1.pdf
75. Leka S, Jain A, Houtman I, McDaid D, De Broeck V, Wynne R. Evaluation of policy and practice to promote mental health in the workplace in
Europe. 2014 Nov.
76. The Finnish Menopause Society. Suomen Menopaussitutkimusseura Finnish Menopause Society [Internet]. [cited 2023 Oct 29]. Available from:
https://menopaussiseura.net/
77. Apotek Hjärtat. Ett initiativ för ökad kunskap om klimakteriet på arbetsplatser [Internet]. [cited 2023 Oct 31]. Available from: https://www.
apotekhjartat.se/klimakteriesakringen/
78. Apotek Hjärtat. Stor okunskap om klimakteriet – var tredje kvinna vet inte vad det innebär. 2022 Mar 1 [cited 2023 Oct 31]; Available from:
https://www.apotekhjartat.se/om-oss/pressrum/pressmeddelanden/stor-okunskap-om-klimakteriet--var-tredje-kvinna-vet-inte-vad-det-inne-
bar/
79. Apotek Hjärtat. Stor okunskap om hur klimakteriet påverkar arbetslivet – apotekskedjan klimakteriesäkrar verksamheten [Internet]. 2022 [cited
2023 Oct 31]. Available from: https://www.apotekhjartat.se/om-oss/pressrum/pressmeddelanden/stor-okunskap-om-hur-klimakteriet-paver-
kar-arbetslivet--apotekskedjan-klimakteriesakrar-verksamheten/
80. Rise. Klimakteriesäkrad arbetsplats [Internet]. [cited 2023 Oct 31]. Available from: https://rise.articulate.com/share/rhRHNsOyYryH7tvjmnCwn-
Er-H2B-krO2#/
81. Regeringen. Tre uppdrag ska bidra till en mer tillgänglig, jämlik och kunskapsbaserad vård för flickor och kvinnor [Internet]. 2023 [cited 2023
Oct 31]. Available from: https://www.regeringen.se/pressmeddelanden/2023/03/tre-uppdrag-ska-bidra-till-en-mer-tillganglig-jamlik-och-kun-
skapsbaserad-vard-for-flickor-och-kvinnor/
82. Socialdepartementet. Uppdrag att genomföra insatser för en jämlik hälso- och sjukvård med fokus på sjukdomar som främst drabbar kvinnor
och flickor [Internet]. Stockholm; 2023 Mar [cited 2023 Oct 31]. Available from: https://www.regeringen.se/contentassets/d658f7f5f8a14b5e-
847f0fc12214c2d5/uppdrag-att-genomfora-insatser-for-en-jamlik-halso--och-sjukvard-med-fokus-pa-sjukdomar-som-framst-drabbar-kvinnor-
och.pdf
83. Regeringen. Uppdrag att genomföra insatser för en jämlik hälso- och sjukvård med fokus på sjukdomar som främst drabbar kvinnor och flickor
[Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.regeringen.se/regeringsuppdrag/2023/03/uppdrag-att-genomfora-insatser-
for-en-jamlik-halso--och-sjukvard-med-fokus-pa-sjukdomar-som-framst-drabbar-kvinnor-och--flickor/
44
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
84. Regeringskansliet, Sveriges Kommuner och Regioner. En personcentrerad, tillgänglig och jämlik mödrahälsovård och förlossningsvård samt
förstärkta insatser för kvinnors hälsa 2023 [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://skr.se/download/18.758d83b4185a9e935
d8b452b/1675069775162/Overenskommelse-forlossningsvard-och-kvinnors-halsa-2023.pdf
85. Sveriges Kommuner och Regioner. Överenskommelser om förstärkta insatser för kvinnors hälsa och förlossningsvården [Internet]. 2023 [cited
2023 Oct 31]. Available from: https://skr.se/skr/halsasjukvard/vardochbehandling/kvinnorshalsa/overenskommelseforattframjakvinnorshal-
sa.12718.html
86. Regeringen. Utgiftsområde 9 Hälsovård, sjukvård och social omsorg [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.regerin-
gen.se/contentassets/e1afccd2ec7e42f6af3b651091df139c/utgiftsomrade-9-halsovard-sjukvard-och-social-omsorg.pdf
87. Sverigedemokraterna, Moderaterna, Kristdemokraterna, Liberalerna. Tidöavtalet: Överenskommelse för Sverige [Internet]. 2022 [cited 2023 Oct
31]. Available from: https://via.tt.se/data/attachments/00551/04f31218-dccc-4e58-a129-09952cae07e7.pdf
88. Sveriges Riksdag. Stärkt vård för kvinnor i klimakteriet [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.riksdagen.se/sv/doku-
ment-och-lagar/dokument/motion/starkt-vard-for-kvinnor-i-klimakteriet_hb021482/
89. Sveriges Riksdag. Jämlik tillgång till hormonbehandling [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.riksdagen.se/sv/
dokument-och-lagar/dokument/motion/jamlik-tillgang-till-hormonbehandling_hb02864/
90. Sveriges Riksdag. Satsning på forskning om kvinnors hälsa och kvinnorelaterade sjukdomar [Internet]. 2023 [cited 2023 Oct 31]. Available from:
https://www.riksdagen.se/sv/dokument-och-lagar/dokument/motion/satsning-pa-forskning-om-kvinnors-halsa-och_hb021904/
91. Region Skåne. Ansökan Uppdrag för Klimakterierådgivning [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://vardgivare.skane.se/
siteassets/4.-uppdrag-och-avtal/lov-lol-lof/tillaggsuppdrag---fillistning/ansokan-klimakterieradgivning.pdf
92. Bohm-Nilsson H. Här får drabbade hjälp mot klimakteriebesvär [Internet]. 2017 [cited 2023 Oct 31]. Available from: https://www.svt.se/nyheter/
lokalt/skane/har-far-drabbade-hjalp-for-klimakteriebesvar
93. Region Skåne. Vi borde prata mer om klimakteriet [Internet]. 2022 [cited 2023 Oct 31]. Available from: https://www.mynewsdesk.com/se/re-
gion_skane/pressreleases/vi-borde-prata-mer-om-klimakteriet-3166585
94. Holm ACS. Klimakteriebesvär i övergångsåldern, vårdprocessprogram [Internet]. 2021 Oct [cited 2023 Oct 31]. Report No.: 5. Available from:
https://ledsys.lio.se/Document/Document?DocumentNumber=14281
95. Region östgötand. Klimakteriebesvär [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://vardgivare.regionostergotland.se/vgw/kun-
skapsstod/kvinnosjukdomar-och-forlossning/klimakteriebesvar
96. Partille Kommun. Friskvårdssatsning kring klimakteriet [Internet]. [cited 2023 Oct 31]. Available from: https://www.partille.se/arbetsmarknad--
jobb/vara-formaner/klimakterieutbildning/
97. Munteanu J. Partille kommun satsar på klimakteriehälsa [Internet]. 2022 [cited 2023 Oct 31]. Available from: https://www.svt.se/nyheter/lokalt/
vast/partille-kommun-forst-i-landet-med-friskvardssatsning-pa-halsa-under-klimakteriet
98. Beskæftigelsesministeriet. Udgivelser [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://bm.dk/arbejdsomraader/udgivelser/
99. Social- B og Æ. Publikationer [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://sm.dk/publikationer
100. Social- og Boligstyrelsen. Udgivelser [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://sbst.dk/udgivelser
101. Sundhedsstyrelsen. Udgivelser [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://sst.dk/da/udgivelser#/side-1
102. Indenrigs- og Sundhedsminsteriet. Publikationer udgivet af ministeriet [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://sum.dk/
publikationer-sundhed
103. Regeringen. Tidligere publikationer [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://www.regeringen.dk/aktuelt/tidligere-publika-
tioner/
104. Ministry of Higher Education and Science. Aftaler om fordeling af forskningsreserve mv. i 2024 [Internet]. 2023 Nov [cited 2023 Nov 6]. Availa-
ble from: https://ufm.dk/aktuelt/pressemeddelelser/2023/filer/endelig-aftale-om-forskningsreserve-for-2024.pdf
105. Deloitte. Insight. 2023 [cited 2023 Oct 29]. International tendens Overgangsalder og menstruation fylder mere på arbejdspladser. Available
from: https://www2.deloitte.com/dk/da/pages/legal/articles/international-tendens-overgangsalder-og-menstruation-fylder-mere-paa-arbejd-
spladser.html
106. Finnish Government. A strong and committed Finland Programme of Prime Minister Petteri Orpo’s Government [Internet]. 2023 [cited 2023
Oct 29]. Available from: https://valtioneuvosto.fi/en/governments/government-programme#/
107. Aamulehti. ”Vaihdevuodet ovat katastrofi tuhansille naisille Tampereella” – Gynekologi Maija Kajan vaatii vaihdevuosipoliklinikan perustamista
[Internet]. 2019 [cited 2023 Oct 29]. Available from: https://www.aamulehti.fi/ihmiset/art-2000007458770.html
108. Kajan M. Vaihdevuosipoliklinikka [Internet]. 2019 [cited 2023 Oct 29]. Available from: https://maijakajan.fi/2019/04/21/vaihdevuosipoliklinikka/
109. Regjeringa. Nasjonal helse- og samhandlingsplan [Internet]. 2022 [cited 2023 Oct 29]. Available from: https://www.regjeringen.no/no/tema/
helse-og-omsorg/innsikt/nasjonal-helse-og-samhandlingsplan/id2913278/
110. Stortinget. Det 168. storting er åpnet [Internet]. 2023 [cited 2023 Nov 14]. Available from: https://www.stortinget.no/no/Hva-skjer-pa-
Stortinget/Nyhetsarkiv/Hva-skjer-nyheter/20232024/det-168.-storting-er-apnet/
111. Stortinget. Stortinget - Møte onsdag den 18. oktober 2023 [Internet]. 2023 [cited 2023 Nov 14]. Available from: https://www.stortinget.no/no/
Saker-og-publikasjoner/Publikasjoner/Referater/Stortinget/2023-2024/refs-202324-10-18?m=2#113008-2-2
112. Weilenmann L. ”Barnmorskor kan behandla kvinnor med klimakteriebesvär” [Internet]. 2020 [cited 2023 Oct 31]. Available from: https://www.
vardfokus.se/yrkesroller/barnmorska/barnmorskor-kan-behandla-kvinnor-med-klimakteriebesvar/
45
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
113. Svenska Dagbladet. ”Barnmorskor nyckel för klimakterievård”. 2020 Feb 21 [cited 2023 Oct 31]; Available from: https://www.svd.se/a/0n7XK0/
barnmorskor-nyckel-for-klimakterievard
114. Vårdförbundet. Förskrivningsrätt för barnmorskor [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.vardforbundet.se/rad-och-
stod/regelverket-i-varden/forskrivningsratt/forskrivningsratt-for-barnmorskor/
115. Lunds Universitet. Populär kurs ger fördjupad kunskap om klimakteriet [Internet]. 2022 [cited 2023 Oct 31]. Available from: https://www.
medicin.lu.se/artikel/popular-kurs-ger-fordjupad-kunskap-om-klimakteriet
116. Lund Universitet. Klimakteriet, menopaus och kvinnors hälsa [Internet]. 2023 [cited 2023 Oct 31]. Available from: https://www.lu.se/lubas/i-
uoh-lu-VMFN77
117. Editor. En sterkere stemme for kvinnehelse [Internet]. 2022 [cited 2023 Oct 29]. Available from: https://sanitetskvinnene.no/nyhet/2022/09/
en-sterkere-stemme-kvinnehelse
118. NHS Employers. Menopause and the workplace [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://www.nhsemployers.org/articles/
menopause-and-workplace
119. LEGO. Let’s talk menopause [Internet]. 2023 [cited 2023 Oct 29]. Available from: https://www.lego.com/en-dk/careers/stories/lets-talk-meno-
pause-?locale=en-dk
46
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
47
SUU, Alm.del - 2023-24 - Bilag 163: Henvendelse af 22/1-24 fra Astellas Pharma om mere oplysning og fokus på overgangsalderen
2814323_0048.png
Astellas Pharma a/s
Arne Jacobsens Allé 15, 2300 København S, Danmark
www.astellas.dk I www.astellas.fi I www.astellas.no I www.astellas.se