SUU, Alm.del - 2019-20 - Bilag 369: Henvendelse af 12/5-20 fra Bo Hembæk Svensson om sammenfaldet mellem Covid og akut toxoplasmose

Sundheds- og Ældreudvalget 2019-20
SUU Alm.del Bilag 369
Offentligt

Copenhagen, May 11

, 2020.

v.2.0

Bo Hembæk Svensson,

Toxoplasma Research

[email protected]

To: Sundhedsministeriet, Sundhedsstyrelsen and Statens Serum Institut

cc: Workinggroup for Tg (FVST)

cc:

Whom it may concern.

CALL TO ACTION.

Highly probable that Covid-19 provokes the onset of acute toxoplasmosis. Pathways and further overlap

elucidated.

This document is a supplement to our previous documents on “Covid/Toxoplasma correlations” of March

and April 20

. Both documents can be found on the homepage of the Parliament of Denmark as exhibit

333 -

here.

Please refer to these for a comprehensive list of overlaps between Toxoplasma and Covid-19.

For further information on Toxoplasma, please see

this

overview article.

Covid-19 keeps surprising as the Coronavirus family usually is related to “common cold”. However Covid-19

displays a set of completely new symptoms for this type of virus and its general pathology;

“..a clear picture is elusive, as the

virus acts like no pathogen humanity has ever seen

”

(Science, April 2020)

There is an almost perfect overlap between the symptoms presented in Covid and in acute toxoplasmosis.

This overlap extends to outcomes, suggested treatments, and pathways for activation of acute

toxoplasmosis. This could explain the “anomalies” of Covid-19.

Toxoplasma is – by far – the most prevalent infection among humans, and its distribution and proliferation

are clearly mirrored in Covid-19 cases, pathology and fatalities

Covid-19

Asymptomatic

Light symptoms

Severe symptoms

Treatments

Pathways/triggers (ie. can Covid-19 trigger acute

toxoplasmosis?)

Same as toxoplasmosis

All suggested Covid-19 treatments has effects on

toxoplasmosis

Yes - Covid can trigger toxoplasmosis

SUU, Alm.del - 2019-20 - Bilag 369: Henvendelse af 12/5-20 fra Bo Hembæk Svensson om sammenfaldet mellem Covid og akut toxoplasmose

Several billion people carry the Toxoplasma parasite in their brains, hearts, kidneys, tissue, etc.

Toxoplasma is an important factor in morbidity:

“All 72 lung cancer patients were infected with T.gondii (prevalence 100%). Of these, 95.8% of

patients showed evidence of active parasite stages. Infection prevalence in the controls (10%)

was significantly lower."

Possible pathway for Covid-19 activation of acute toxoplasmosis (i.e provoked egress)

“Covid-19 seems to create a high concentration of Ca2+, which is the trigger for synchronous egress of

Toxoplasma tachyzoites which leads to acute toxoplasmosis.”

1. Ca2+ pathway for Covid-19 activation of acute toxoplasmosis

Covid-19: Lysosomal and plasma membrane TRPM2,

cause Ca2+ influx across the plasma

membrane

and release of lysosomal Ca2+,

providing high concentration of Ca2+

in the

cytosol. The overload of cytosolic Ca2+ initiates apoptosis and probably necrosis”

b. Toxoplasma: “Egress can be artificially induced by Ca2+ ionophores” and “

Synchronous

egress can be triggered by Ca2+

”

(Please note that Hydroxychloroquine slows Ca2+, hence slows down the development of acute

toxoplasmosis: “treatment with hydroxychloroquine is associated with a dose-dependent

downregulation of the co-stimulatory molecule CD154 on CD4+ T cells, which is accompanied by a decrease

in intracellular Ca2+ mobilization “)

Examples of further indications on the correlation between Covid-19 and Toxoplasma keeps emerging:

2. Kawasaki-disease among children

a. Covid-19: “New York warns of children's illness linked to Covid-19 after three deaths”

b. Toxoplasma: "Juvenile polyarteritis nodosa associated with

toxoplasmosis presenting as

Kawasaki disease.

3. Overrepresentation of patients that are obese

a. Covid-19: “COVID-19 can cause more severe symptoms and complications in some people

living with obesity (WHO)”

b. Toxoplasma: “

Toxoplasmosis is associated with obesity

by alteration of inflammatory fat

distribution as organisms alter and reside in fatty tissues “

4. Endothelial disease

a. Covid-19: “Severe COVID-19 infection associated with endothelial activation” and “The

symptoms most commonly reported by patients affected by coronavirus disease 2019

(COVID-19) include cough, fever, and shortness of breath. However, other major events

usually observed in COVID-19 patients (e.g. high blood pressure, thrombosis, pulmonary

embolism) seem to suggest that the virus is targeting the endothelium, one of the largest

organs in the human body.”

SUU, Alm.del - 2019-20 - Bilag 369: Henvendelse af 12/5-20 fra Bo Hembæk Svensson om sammenfaldet mellem Covid og akut toxoplasmose

b. Toxoplasma: “Acute toxoplasmosis is associated with significant oxidative stress and

pro-inflammatory changes which contribute to development of

endothelial dysfunction

.”

and “Infection with Toxoplasma gondii leads to activation of T-helper cells (Th-1 and Th-2)

which are involved in the synthesis and release of different cytokines which may lead to

endothelial dysfunction.”

5. Olfactory dysfunction/anosmia

a. Covid-19: “..anosmia, with or without dysgeusia, are symptoms frequently associated with

severe Covid-19..”

b. Toxoplasma: “..chronic latent neuroinflammation caused by the parasite may be

responsible for the development of several neurodegenerative diseases

manifesting with

the loss of smell

. Studies (..) revealed cysts in various regions of the brain, including

olfactory bulb

.”

6. Lowered levels of estrogen/estrogen therapy

a. Covid-19: “Estrogen therapy could be used to treat male coronavirus patients”

b. Toxoplasma: "..results also showed that the acute toxoplasmosis always related with low

concentration of both progesterone and estrogen"

7. Vitamin D deficiency

a. Covid-19: “there is a potential association between mean levels of vitamin D in various

countries with cases and mortality caused by COVID-19”

b. Toxoplasma: “..the difference in prevalence of T. gondii infection in two groups of vitamin D

sufficient and deficient individuals was noticeable and

Toxoplasma infection was

associated with vitamin D deficiency

.”

8. Psycosis & skizophrenia

a. Covid-19: “...researchers are investigating a potential secondary, long-term impact of

COVID-19 exposure — greater susceptibility to psychosis” and “COVID-19 outbreak

increased risk of schizophrenia in aged adults”

b. Toxoplasma: “If there is one thing that Toxoplasma correlates to, it is schizophrenia and

psychosis”

It is so that virtually every time we see something “novel” in relation to Covid-19, it is mirrored in acute

toxoplasmosis.

There is no protocol in place that tests patients and/or deceased for the presence of Toxoplasma

tachyzoites/acute toxoplasmosis. This means that the above is not yet being investigated/accepted as

part of Covid-19 pathology.

All quotes above are from peer-reviewed material. We will be happy to share this with anyone willing to

assist in the elucidation of the above correlations.