Udvalget for Forskning, Innovation og Videregående Uddannelser 2012-13
FIV Alm.del Bilag 117
Offentligt
The Weizmann Instituteof Science for the Benefit of SocietyMudi Sheves, Vice President for Technology TransferThe Weizmann Institute
The Weizmann Institute of Science
Curiosity Driven Research
Weizmann Approach:Basic Research LandscapeBasic Science onlyPhysicsImbedded multidisciplinaryapproach
Mathematics
Graduate school andPublic Education
Biology
High level education program
Chemistry
Technology transfer-Yeda
What will be the next scientific revolution?
Who will make the next scientific revolution?
The next scientific revolution will be driven by scientists whohave a multidisciplinary view of science,the opportunity to take risks,the infrastructure to work,and the freedom to think.
We invest in excellent people with excellent ideas
Curiosity driven
The Weizmann Institute of Science2009 Nobel Prize in Chemistry
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Applied vs Basic
Demand driven
Curiosity driven
From Basic Science to Products:The Linear ModelBasicScienceAppliedResearch
IIIIndustrialDevelopmentProducts
III
IV
To succeed in science you need 3G’sPaul Ehrlich (1902)Gedacht= Original IdeasGeduld= Patience
Geld!!=Money !!
Trends in Government Support
FACTS ANDFIGURES
60.00%55.00%50.00%45.00%40.00%35.00%30.00%
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
1996/797/9898/9999/0000/0101/0202/0303/0404/0505/0606/0707/08
Weizmann BudgetBudget: ~$300 M8% Financial andother revenues34% Governmentof Israel23%Researchgrants
35% Donations and endowment
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science
w w w .Yeda R n D .c om
Technology Transfer Tradition1915
Professor Chaim Weizmann invented a new bio-technologicalmethod to produce acetone from starch while working as aResearcher at the University of Manchester.Weizmann (that owned over 100 patents) applied for apatent and transferred the technology to the British Navy.Weizmann was appointed to head the NavyLaboratories, which successfully mass produced acetonewhich was used to produce explosives during WWI.After the war, this became the common industrialmethod for Acetone production.Weizmann Established the Daniel Sieff ResearchInstitute, which later became the WeizmannInstitute of Science.Weizmann became Israel’s first president.
1916
1917
1934
1948
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science
w w w .Yeda R n D .c om
"Everything that can be invented has been invented“CHARLES H. DUELL, Commissioner US. Office of patents,1899.
U.S. patents granted, 1790–2010.
U.S. Patent Statistics ChartCalendar Years 1963 - 2010600.000500.000400.000300.000200.000100.0000196419661968197019721974197619781980198219841986198819901992199419961998200020022004200620082010Patent GrantsPatent Applications
“It’s tough to make predictions, especially about thefuture”Niels Bohr
•“Whothe hell wants to hear actors talk?"Harry M. Warner, Warner Bros., 1927.
•"I think there is a world market for maybe fivecomputers"THOMAS WATSON, chairman of IBM, 1943•"There is no reason for any individuals to have acomputer in their home"KEN OLSEN, president, andchairman of Digital Equipment Corp, 1977
Basic Science:The serendipity modelX-ray
Serendipity:The faculty of makingfortunate discoveriesby accident.
Röntgen
Crookes tube
Röntgen was “playing” with a Crookes tube,and tried to understand the behaviorof electric current in such a device.
Röntgenwife’s hand
Basic science:The initiallyunknown applications
Atomicclock
GPS: Global Positioning System
Theory ofrelativity
Basic Scienceis notResearch and DevelopmentFaraday's experiments on electricity,were driven by curiosity but broughtus in the modern era of electricity.
Michael Faraday1791-1867
Electric light came from innovation driven by basic science.
No amount of R&D on the candlecould ever have done that.
Technological developments arefueled byscientific innovationscoming from academia. Therefore,
transfer of new ideas and discoveriesfrom academia to the private sectorisessential to the industry.
toolittle
of the“Society, having funded muchuniversity based research, has anexpectation that the fruits of thatresearch will improve the human
condition.”NielsReimers, 1987
Academic tech. Transfercompanies in IsraelWeizmann InstituteHebrew University
YedaYissum
19591964
Tel Aviv University
Ramot
1973
1980’s
1990’s
1998
AcademiaThe deathvalley
Industry
BTGFunds
OCS toolsIncubatorsAngels
Expenditure on Civilian R&DPercent of the GDP - Israel and OECD Countries54.5
43210
3.6 3.4
3.2 3.22.72.52.3 2 2.2.1 2.0 2 0.1.9 1 8.
1.6 1.6 1.6
1.4 1.4 1.4
1.1 1 0 1.0.
0.9 0.9
0.7
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science
Source: OECD and Israel CBSw w w.YedaRnD.com
Yeda / Weizmann Success StoriesSelected Success StoriesCOPAXONE�
Indicated for Multiple SclerosisCOPAXONE representsa newclass of drugsfor the treatmentof the diseaseCopaxone is a synthetic copolymeracting as an immunomodulator
1971: First Patent filed by Yeda1987: Licensed to TevaPharmaceuticals Ltd.
2012 Sales:$US 4 Billion
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Yeda Research & Development Co. Ltd.Combining Benevolence & Business
Allow society to benefitfrom discoveries made at the Weizmann Institute ofScience.Effectively commercialize technologiesdeveloped at Weizmann to createadditional income for the Institute.330058%56%52%48%44%40%36%32%28%24%20%16%12%8%4%28002600240022002000180016001400120010008006004002000Global Market Share(%)
Sales ($M)
2002
2003
2004
2005
2006
2007
2008
2009
2010
Source: Annual Companiesreports for- Copaxone, Rebif& Avonex
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Yeda Research & Development Co. Ltd.Combining Benevolence & Business
Allow society to benefitfrom discoveries made at the Weizmann Institute of Science.Effectively commercialize technologiesdeveloped at Weizmann to createadditional income for the institute.330041.0%27.3%
58%56%52%48%44%40%36%32%28%24%20%16%12%8%4%
2002
2003
2004
2005
2006
2007
2008
2009
2010
28002600240022002000180016001400120010008006004002000
Global Market Share(%)
Source: Annual Companiesreports for- Copaxone, Rebif& Avonex
Sales ($M)
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Yeda / Weizmann Success StoriesSelected Success StoriesErbituxTM
Erbitux is an antibody based therapypresenting synergism with conventionalchemotherapy.The synergistic effect was inventedby Prof.Sela’sgroup at WIS between1987-88.
Erbitux was developed by ImCloneSystems and approved by the FDA in2001.Estimated yearly sales - $1.5 billion.
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
A Drug for Type 1 Diabetes Developed byProf. Irun Cohen–Phase IIIDiaPep277�is a unique peptide,containing 24 amino acids, is derivedfrom the sequence of the human heatshock protein 60 (Hsp60).The peptide acts by modulating theimmune system, preventing thedestruction of the pancreatic cellsthat secrete insulin.It appears that the patients treatedwith the drug for a year or more hadsignificantly higher pancreas functionthan those in the control group.Licensed to Andromeda Biotech.
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science
w w w .Yeda R n D .c om
Yeda / Weizmann Success StoriesSelected Success StoriesNanoLubNanoLubTMis the world's firstcommercial solid lubricant based onspherical inorganic nanoparticles.NanoLubTMreduces friction & wearsignificantly better than conventionallubricants.2002: Licensed to Nanomaterials Inc.Potential Uses:oils & greasesimpregnating partspolymercomposite films & metal compositecoatingsYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.comTM
Yeda Research & Development Co. Ltd.a world leader in Technology TransferDozens of “Weizmann-Inside” products on the market.
Total annual Weizmann products sales in 2012:21 Billions $.Over 40 new companieswere established around Yeda’stechnologies – 24 in the last 6 years.Yeda owns a largest portfolio of patents in Israel:600 live patent families,with over 1,500 patent familiesfiled since 1971.
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Yeda Research & Development Co. Ltd.Licensing IncomeLicensing Income Survey 2010 top 10 Universities*Institution12345678City of Hope National MedicalCenter. & Beckman ResearchNorthwestern Univ.NYUColumbia Univ.Sloan Kettering Inst. For Cancer Res.Univ. California SystemWake Forest Univ.Univ. of MinnesotaThe General Hospital dbaMassachusetts General Hos.Univ. of Washington
Licensing Income ($M)202179
17814713910485837769* Source: AUTM Licensing Survey 2010
910
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
How?
Yeda Research & Development Co. Ltd.FavorableEnvironmentalConditionsLegal structure similar to Bayh-Dole actIP owned by the InstitutionSharing royalty with the inventorsGovernment support programsIncubatorsDirect tech transfer support programsDeveloped VC community, Entrepreneurs
Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w.YedaRnD.com
Internal Conditions forsuccessful Tech Transfer• Scientists’ focus on excellence inBasicScience,not on commercialization.• Apro-activetech transfer operation.• Tech Transfer officers: background inBusiness and Academia.• A few years of investment by theUniversity (patents, marketing,agreements) before income is generated.• Clearinternal IP rules,enforced byUniversity management.
However!Academy-Industry cooperation, as
love making between hedgehogs.It isa desired activity that has to beexercised with extreme caution.
Thank you for your attention
